The exact timing and contribution of epigenetic reprogramming to carcinogenesis are unclear. Women harbouring BRCA1/2 mutations demonstrate a 30-40-fold increased risk of high-grade serous extra-uterine Müllerian cancers (HGSEMC), otherwise referred to as 'ovarian carcinomas', which frequently develop from fimbrial cells but not from the proximal portion of the fallopian tube. Here we compare t...

Recently, the distal Fallopian tube has attracted considerable attention not only as site of origin for serous cancer in women with BRCA mutations, but also as the anatomical location where the majority of serous ovarian cancers apparently develop. Consequently, the Fallopian tube may be the unique location where early ‘ovarian’ cancers can be found—which would contradict the long-standing impr...

Primary fallopian tube cancer in pregnancy is rare and is even more so for the clear cell variant. Our case is the third case of primary fallopian tube cancer in pregnancy and the first case of clear cell adenocarcinoma of the fallopian tube in pregnancy. The patient presented with increasing pelvic pain starting in the second trimester. Serial ultrasound evaluations were performed and revealed...

Introduction: There has been a scarcity of cases of isolated fallopian tubes torsion in the literature. Case Description: Isolated fallopian tube torsion in a 27-year-old woman was associated with a hydrosalpinx. Laparoscopic detorsion of the right fallopian tube was performed within 24 hours of the onset of clinical symptoms. Surgical management was based on evaluation of tubal status and visu...

s and presentations • Dean M, Canestrari E, David D, Burdette JE. (2016) Ovarian Secretome Profiling Identifies Proteins that Stimulate Migration of the Fallopian Tube Epithelium: A Mechanism for Initial Metastasis of High Grade Serous Cancer. 49 Annual Meeting for the Society for the Study of Reproduction National Meeting, San Diago, CA. * Lalor Foundation Merit Award • Dean M, David D, and Bu...

The fallopian tube plays an important role in successful female reproduction because it transport gametes to the fertilisation site, nourishes the developing embryo and transports the embryo to the uterus at a suitable time for implantation. The overall aim of this thesis was to investigate the role of progesterone in the control of gamete transport. Ciliary cells are important for the transpor...

Epidemiological studies have shown that cigarette smoking is a major risk factor for tubal ectopic pregnancy but the reason for this remains unclear. Here, we set out to determine the effect of smoking on Fallopian tube gene expression. An oviductal epithelial cell line (OE-E6/E7) and explants of human Fallopian tubes from non-pregnant women (n = 6) were exposed to physiologically relevant conc...

Adnexal torsion accounts for 2.7% of all gynaecological emergencies, but isolated torsion of fallopian tube is an infrequent yet significant cause of lower abdominal pain in women, which generally presents in the reproductive age group. The overall incidence is 1 in 1.5 million women and is generally isolated and unilateral.(1) Patients typically present with intermittent pain related to torsio...

Hereditary breast and ovarian cancer syndrome carries significant mortality for young women if effective preventive and screening measures are not taken. Preventive salpingo-oophorectomy is currently the only method known to reduce the risk of ovarian cancer-related death. Histopathological analyses of these surgical specimens indicate that a high proportion of ovarian cancers in women at high ...