This paper describes a robust optimization methodology for designs involving either complex simulations or actual experiments. The methodology adopts a new objective function which consists of an Expected Performance (EP) and a weighted Quality Index (QI). This definition enhances the measure of optimality and robustness. This paper introduces the Quadrature Factorial Experiment to estimate the...

Nateglinide is a novel, highly physiologic, glucose regulator recently approved for the treatment of type-2 diabetes mellitus. Nateglinide has a rapid onset and short duration of insulinotropic action that results in reduction of glucose level. The purpose of this study to develop a floating tablet of Nateglinide to enhance its bioavailability and sustained action. In the present study a 32 ful...

In this paper, factorial design experiments and Taguchi methods have been used to monitor the quality of the incoming raw material, product quality during processing, and the final product quality of a process industry. The data collected and results obtained are presented and discussed. The analysis made on the experimental results provided information to improve the quality of the process ind...

a controlled release matrix formulation for mesalamine was designed and developed to achieve a 24 h release profile. using compritol 888 ato (glyceryl behenate) as an inert matrix-forming agent to control the release of mesalamine, formulation granules containing the solid dispersions were investigated. pectin, a polysaccharide, was used as bacterial dependent polymer for colon targeting. the m...

A 23 factorial experimental design has been used to quantitatively study individual and interaction effects of the nature of binder (N), concentration of binder (C) and the applied pressure (P) on two mechanical properties, namely, tensile strength (TS) and brittle fracture index (BFI), of paracetamol tablets. The factorial design was also used to study the quantitative effects of coprocessing ...

Saline waters treatment has become increasingly important for drinking water supply in a greater part of the world. However, some serious limitations had recently been discovered during water treatment, among them the boron problem seems to have a critical meaning. According to the WHO regulations (2011), the boron concentration should be reduced to less than 2.4 mg/L for drinking water. The pu...

A bacterium, Pseudomonas aeruginosa (ATTC27853), was investigated for its ability to grow and to degrade phenol as sole carbon source, in aerobic batch culture. The parameters which affect the substrate biodegradation such as the adaptation of bacteria to phenol, the temperature, and the nature of the bacteria were investigated. The results show that for a range of temperature of 30 to 40°C, th...

FAC-SEM is a special type of multigroup analysis where the groups are structured as a factorial design. The aim of FAC-SEM is to assess how the path model parameters vary as a function of the dimensions of the underlying factorial design. As such, FAC-SEM offers researchers a unique opportunity to further understand their experimental data. This paper explains how the FAC-SEM methodology can be...