Introduction and purpose: 
 This review aims to analyze BRAF mutation significancy its influence on progression therapy methods within patients with melanoma. Material method: was mainly based articles collected in Pubmed years 2004-2018. The research done by looking through keywords as follows “braf kinase”, mutation”, “melanoma” “wemurafenib”. Results: selected studies have demonstrated ...

PURPOSE Uveal melanoma is a rare melanoma variant with no effective therapies once metastases develop. Although durable cancer regression can be achieved in metastatic cutaneous melanoma with immunotherapies that augment naturally existing antitumor T-cell responses, the role of these treatments for metastatic uveal melanoma remains unclear. We sought to define the relative immunogenicity of th...

Did you know the reason behind wearing sunscreen is more than just preventing a sunburn? Sun damage to skin over lifetime can lead most dangerous type of cancer, called melanoma. Melanoma abnormal growth pigment-producing cells skin, same types that make up moles. Though rare in young people, risk for melanoma increases with age. kids looks and acts differently it does adults, often making diag...

bebig ruthenium-106 ophthalmic plaques have been used for treatment of uveal melanoma, retinoblastoma, melanoma of the iris and other special applications for many years. the plaques consist of a thin film of 106ru, a beta emitter, encapsulated in pure silver. the present work proposes a new mathematical eye model for ophthalmic brachytherapy dosimetry. this new model includes detailed descript...

Cutaneous malignant melanoma is the fastest increasing malignancy in humans. Hepatoma-derived growth factor (HDGF) is a novel growth factor identified from human hepatoma cell line. HDGF overexpression is correlated with poor prognosis in various types of cancer including melanoma. However, the underlying mechanism of HDGF overexpression in developing melanoma remains unclear. In this study, hu...

EYA1 is a DNA repair enzyme that is induced after DNA damage and is upregulated in melanoma. However, its role in pathogenesis and therapeutic targeting of melanoma is unknown. Our objectives are (1) to study the relationship between EYA1 expression levels and melanoma patients' clinical pathologic parameters including survival; (2) to investigate its impact on cultured melanoma cells in vitro;...

background and objective: the frequency and pattern of eye neoplasms differ in various geographic areas. our aim was to determine the distribution of patient age, gender, ocular tumor origin, location and histological type in our region. materials and methods: in this cross-sectional study, all of the 384 eye globe enucleation cases carried out during a 10-year period in farabi medical center i...

In xiphophorine fish suffering from a genetically caused melanoma, both suppression of melanoma development and regression of the existing melanoma were observed after treatment of the fish with an "anti-melanoma immune RNA." This RNA was extracted from the lymphoid organs of guinea pigs immunized with fish melanoma. RNA from guinea pigs immunized with fish skin or liver and RNA from nonimmuniz...

Melanoma is the most aggressive skin cancer and responsible for majority of deaths. Despite advances in treatment, our current prognostic indicators are poor fail to adequately risk-stratify patients. This study evaluates concentration, size, proteomic metabolomic profile circulating extracellular vesicles (EVs) isolated from plasma patients with melanoma, identify potential biomarkers disease ...

Melanoma, an aggressive malignancy of melanocytes, is responsible for more deaths than any other skin cancer. Despite the fact that there a long lag period before premalignant dysplastic nevi become invasive melanomas, has been little progress in developing new methods melanoma prevention. Using animal model melanomagenesis, we examined whether administration anti-PD-L1 antibodies, effective im...