A 42-year-old female patient was admitted due to epigastric pain and weight loss. Her past medical history was otherwise negative apart from cigarette smoking. Her physical examination was unremarkable. C-reactive protein and erythrocyte sedimentation rate were raised up to 14.8 mg/ dL and 51 mm/h respectively, platelets were 453,000, while the remaining laboratory tests were normal. Upper gast...

Primary bone marrow diffuse large B-cell lymphoma (DLBCL) is a rare type of extranodal lymphoma with poor prognosis. Here, we report a case of primary bone marrow DLBCL successfully treated with high-dose chemotherapy and rescued by in vivo rituximab-purged autologous stem cells. A 39-year-old woman visited our hospital because of anemia. Bone marrow examination revealed a large B-cell lymphoma...

Non-Hodgkin’s lymphoma (NHL) is the third most frequent malignant tumour in the head and neck, basocellular carcinoma of the skin and mucosal squamous cell carcinoma being the most frequent. Although nodal enlargement is the most common presentation in the head and neck, NHL may occur in extranodal locations. Two distinct extranodal sites are recognised: extranodal lymphatic locations or involv...

Aberrant expression of microRNA (miR-155) has been reported previously in several hematological malignancies [1,2,3,4]. Recently, Bedewy et al. [5] published their excellent findings in this journal. They reported that miR-155 expression was significantly upregulated in patients with B-cell non-Hodgkin lymphoma (NHL) compared with normal controls. In patients with B-cell NHL, a high level of mi...

BACKGROUND Secondary immune thrombocytopenic purpura (ITP) associated with extranodal B-cell non-Hodgkin's lymphoma (NHL) is extremely rare. The optimal management is not established. We report a first case of ITP in association with extranodal B-cell NHL originating in the lower petroclival region, successfully managed by local tumor control using conventional radiotherapy. CASE DESCRIPTION ...

OBJECTIVE Diffuse large B-cell lymphoma is the most common type of non-Hodgkin lymphoma, accounting for nearly 50% of the cases in the Hematology Department of the Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo and Instituto do Câncer do Estado de São Paulo. The treatment outcome is influenced by age, abnormal lactate dehydrogenase levels, extranodal infiltration, t...

The translocation of chromosome 11, long arm, region 2, band 1, to chromosome 18, long arm, region 2, band 1 (t(11;18)(q21;q21)) represents a recurrent chromosomal abnormality in extranodal marginal zone B-cell lymphoma (MZBCL) of mucosa-associated lymphoid tissue (MALT) type and leads to a fusion of the apoptosis inhibitor-2 (API2) gene on chromosome 11 and the MALT lymphoma-associated translo...

Mature or peripheral T-cell lymphomas are uncommon, accounting for only 10%-15% of all non-Hodgkin's lymphomas. The classification of these neoplasms has been controversial. In contrast to B-cell lymphomas, cytologic grade has not been very useful in predicting the clinical course. This finding may result from the generally aggressive clinical course associated with T-cell lymphomas. Prior stud...

A retrospective study was made to determine relative incidence of lymphoma subtypes in Malaysia. High grade non-Hodgkin's lymphoma was found to be common. Low grade non-Hodgkin's lymphoma and Hodgkin's disease were relatively rare in this Malaysian series. Non-Hodgkin's lymphoma of B-cell immunophenotype was four times as common as that of T-cell lineage. There was a high incidence of primary e...