Melatonin is used in the therapy of sleep and mood disorders and as a neuroprotective agent. The aim of our study was to demonstrate that melatonin supported (via its deacetylation to 5-methoxytryptamine) CYP2D-mediated synthesis of serotonin from 5-methoxytryptamine. We measured serotonin tissue content in some brain regions (the cortex, hippocampus, nucleus accumbens, striatum, thalamus, hypo...

The relationship between exogenous melatonin applied into cucumber seeds during osmopriming and modifications of their antioxidant defense was studied. Accumulation of hydrogen peroxide, antioxidant enzyme activities and glutathione pool were investigated in embryonic axes isolated from the control, osmoprimed, and osmoprimed with melatonin seeds. Germinating cucumber seeds are very sensitive t...

Cucumber (Cucumis sativus L.) is sensitive to the salinization of environment. Soil in facility environment affects yield and quality cucumber. Melatonin (N-acetyl-5-methoxytryptamine) an effective free radical scavenger plants could effectively alleviate abiotic stress injury plants. In this study, we investigated effect different concentrations exogenous melatonin mitigating salt cucumber som...

In humans, the nocturnal fall in internal temperature is associated with increased endogenous melatonin and with a shift in the thermoregulatory control of skin blood flow (SkBF), suggesting a role for melatonin in the control of SkBF. The purpose of this study was to test whether daytime exogenous melatonin would shift control of SkBF to lower internal temperatures during heat stress, as is se...

The effects of exogenous melatonin on reproductive performance of 737 Polypay and Polypay-cross ewes were evaluated during a late March and April breeding period. Different concentrations (2 or 10 mg) routes of administration (fed vs implanted) and durations of administration (20 or 40 d before breeding) were studied. Estrus was synchronized in all ewes using 60 mg medroxyprogesterone acetate (...

Artificial illumination is an important exogenous factor in the control of many physiological and behavioral processes as well as an important environmental factor in the management of laying hens. Melatonin receptors are members of the G protein-coupled receptor family. The hormone melatonin is secreted primarily by the pineal gland, with highest levels occurring during the dark period of a ci...

OBJECTIVE The effects of exogenous melatonin on sleep, daytime sleepiness, fatigue, and alertness were investigated in 22 patients with delayed sleep phase syndrome whose nocturnal sleep was restricted to the interval from 24:00 to 08:00 hours. This study was a randomized, double-blind, placebo-controlled crossover trial. Subjects received either placebo or melatonin (5 mg) daily for 4 weeks, u...

OBJECTIVES: Melatonin, the major secretory product of the pineal gland, is known as an effective antioxidant and neuroprotector. Its neuroprotective actions and mechanisms have been documented in a variety of rodent brain models. However, little is known of melatonin’s antioxidative capacity in the brain of primates. Herein, we investigated whether melatonin would suppress autoxidation and exog...

The unprecedented early spring frost that appears as a cold stress adversely affects growth and productivity in tea (Camellia sinensis L.); therefore, it is indispensable to develop approaches to improve the cold tolerance of tea. Here, we investigated the effect of pretreatment with exogenous melatonin on the net photosynthetic rate, the maximum photochemical efficiency of PSII, chlorophyll co...

© 2016 Indian Journal of Anaesthesia | Published by Wolters Kluwer Medknow Ever since Aaron Bunsen Lerner isolated melatonin (N-acetyl-5-methoxytryptamine) from pineal glands of cattle in 1958, the hormone has been found to have several uses in humans. Endogenous melatonin is well recognised for its role in regulation of the circadian rhythm.[1] Exogenous melatonin has been studied for various ...