background: multiple sclerosis (ms) is a neurological disease with a variety of signs and symptoms. exercise therapy has been shown to improve physical functions in ms. however, questions about an optimal exercise therapy remain. in this regard, we suggest a combined exercise therapy including aerobic and resistance exercises for ms patients. the study is designed to observe, test and compare t...

recently, the role of myostatin (mstn) in controlling insulin resistance (ir( has been known. the aim of this study was to determine acute and delayed response of mstn and ir to circuit resistance exercise. for this purpose, 12 healthy men volunteered and participated in 2 sessions of the resistance exercise and control with one-week interval. after a session to instruct how to perform resistan...

the purpose of this study was to examine the effects of omega3 and aerobic exercise intervention on the calcium metabolism regulating hormones in non – athlete postmenopausal women. for this purpose 40 healthy non – athlete postmenopausal women with age 57.72±3.53 years, height 157,75±9,24 cm, weight 58.08±12.76kg, bmi 23.78±3.73kg/m2, fat 23.18±4.68% volunteered in this study. subjects in a do...

The bifunctional enzyme methylenetetrahydrofolate dehydrogenase - cyclohydrolase (FolD) is identified as a potential drug target in Gram-negative bacteria, in particular the troublesome Pseudomonas aeruginosa. In order to provide a comprehensive and realistic assessment of the potential of this target for drug discovery we generated a highly efficient recombinant protein production system and p...

Purpose This study aimed to verify whether cold artifacts caused by the gap state between attenuation correction computed tomography (ACCT) and positron emission (PET) data (so-called hot-in-air (HIA) state) in body trunk PET/computer (CT) examinations can be improved Absolute-single scatter simulation (SSS), which is a method phantom experiment using high-accumulation syringe of out-of-body ph...

purpose this study was designed to assess the effects of ramadan fasting on the profile of mood state and perceived exertion in young soccer players and aerobic and anaerobic performances during the yo-yo, repeated sprint ability (rsa) and the wingate tests. methods twenty junior male soccer players completed the yo-yo, the rsa, and the wingate tests on three different occasions: one-week befor...

This paper looks at the historical evolution of the relationship between an economy's structure and the corresponding political system, starting from feudal times. We show why, in an early agricultural phase, aristocratic political systems prevail, while democracies tend to emerge with the industrial phase, while at the same time the legal system regulating the intergenerational transfers of pr...

This paper establishes a simple model of long run economic and political development, which is driven by the inherent technical features of di¤erent production factors, and political con‡icts among factor owners on how to divide the outputs. The main capital form in economy evolves from land to physical capital and then to human capital, which enables their respective owners (landlords, capital...

Microplate reader assays offer several advantages over conventional spectrophotometric assays. We adapted the dihydrofolate reductase (DHFR) enzyme inhibition assay for use in a 96-well microplate reader to measure plasma methotrexate (MTX) concentrations. The assay is linear from 0.01 to 0.1 micromol/L. The within-run CVs at 0.03 micromol/L and 0.08 micromol/L MTX were 4.0% and 2.7%, respectiv...