HE male determining influence of the autosomes on sex differentiation T in Drosophila melanogaster was proven by BRIDGES in 1921 with the discovery of triploid intersexes. He found that individuals with two X chromosomes, as in diploid females, and three of each autosome (3A) develop intersexually. BRIDGES concluded that sex is determined by an interplay of female determining genes located prin...

Rad53 and Mec1 are protein kinases required for DNA replication and recovery from DNA damage in Saccharomyces cerevisiae. Here, we show that rad53, but not mec1 mutants, are extremely sensitive to histone overexpression, as Rad53 is required for degradation of excess histones. Consequently, excess histones accumulate in rad53 mutants, resulting in slow growth, DNA damage sensitivity, and chromo...

in this work, we consider each normal alkane as a hypothetical mixtureof methyland methylene groups, in which the interaction potential of each pair is assumed to be the average effective pair potential. then, the lir equation of state (eos) is extended for such a hypothetical mixture. also, three basic compounds, namely, propane, n-butane and cyclohexane, are used to obtain the contribution of...

OBJECTIVE To determine the frequency of "signature" chromosomal abnormalities in oncology workers handling anticancer drugs. METHODS Peripheral blood from health care personnel (N = 109) was examined with probes for targets on chromosomes 5, 7, and 11. The effect of drug-handling frequency on chromosome abnormalities was assessed. RESULTS An excess of structural (0.18 vs 0.02; P = 0.04) and...

this study assessed the optimum water need of pepper (capsicum annuum l. cv. california wonder) and the critical irrigation level to be applied in order to achieve a reasonable economic yield in water shortage conditions. in a controlled field experiment involving five different treatments, seasonal evapotranspiration for pepper fluctuated from 89 mm in the severe stress treatment (i0.00) to 1,...

A system to detect a minimal function of Saccharomyces cerevisiae centromeres in vivo has been developed. Centromere DNA mutants have been examined and found to be active in a plasmid copy number control assay in the absence of segregation. The experiments allow the identification of a minimal centromere unit, CDE III, independently of its ability to mediate chromosome segregation. Centromere-m...