In the current work, prolonged systemic delivery of apomorphine via buccal mucosa was shown to be a promising treatment for Parkinson's disease as substitute clinically utilized subcutaneous infusions. Due extensive ‘first-pass’ metabolism, is administered parenterally bypass liver metabolism. Drawbacks parenteral administration cause low patient compliance and adherence treatment. On other han...

Oral delivery of antipsychotic drugs like Ziprasidone HCl has a disadvantage gastric disturbance and lack adherence to the treatment. In present study, loaded ethosomal gel was formulated avoid disadvantages oral delivery. The ethosomes were prepared using Lipoid S 75 with Isopropyl alcohol Propylene glycol as solvents. evaluated for different parameters particle size, poly dispersibility index...

Ex vivo expansion of human umbilical cord blood cells (HUCBC) is explored by several investigators to enhance the repopulating potential of HUCBC. The proliferation and expansion of human hematopoietic stem cells (HSC) in ex vivo culture was examined with the goal of generating a suitable clinical protocol for expanding HSC for patient transplantation. Using primary human mesenchymal stem ...

Ocular drug delivery in hydrogel forming film form has several benefits over conventional dosage forms. An ophthalmic anti-inflammation study was undertaken using topically applied aspirin a formulation. A hydroxypropyl methylcellulose (HPMC) matrix formulation prepared by the solvent casting and evaporation technique taking triethanolamine (TEA) as plasticizer. Ex vivo corneal permeation well ...

The purpose of this study was to explore the potential formulating hesperetin into an ophthalmic solution with dipotassium glycyrrhizinate (DG) as a micelle nanocarrier. A DG-based encapsulating (DG-Hes) developed and its in vitro/in vivo characterizations were evaluated. optimal formulation featured DG/hesperetin (Hes) weight ratio 12:1 encapsulation efficiency 90.4 ± 1.7%; optimized DG-Hes ch...

In this study, a thermosensitive in situ gel nanoemulsion was formulated by low energy method for intranasal delivery of temozolomide to bypass the blood-brain barrier and optimize chemotherapy glioblastoma. Various amounts Labrasol, Transcutol®P, Triacetin were chosen as components based on solubility partial pseudoternary phase diagrams studies. Poloxamer derivatives added selected gelling te...

Pickering emulsions (PEs) are attracting increasing attention in the areas of food, cosmetic and pharmaceutical applications owing to their surfactant-free eco-friendly nature. Herein, PEs stabilized by chitosan/collagen peptides (CH/CP) nanoparticles were assessed as green vehicles for topical delivery cannabidiol (CBD), a highly lipophilic unstable drug that is finding an appeal market. The i...

Purpose: To formulate Eudragit RS 100-based nanoparticles containing metronidazole (MTZ NPs) and incorporate them into hydrogels using different gelling agents for controlled release in the buccal mucosa.
 Method: MTZ NPs were fabricated nanoprecipitation method. (1 % w/w) introduced excipients. Physicochemical properties of NPs, mucoadhesive strength spreadability hydrogels, ex vivo perme...

The objective of this investigation was the development of chitosan/xanthan polyelectrolyte complex based mucoadhesive nasal insert of promethazine hydrochloride a drug used in the treatment of motion sickness. A 32 factorial design was applied for preparing chitosan/xanthan polyelectrolyte complex and to study the effect of independent variables i.e. concentration of xanthan [X1] and concentra...