نتایج جستجو برای: ex vivo lung perfusion

تعداد نتایج: 696272  

Journal: :PLOS ONE 2021

Use of normothermic ex vivo lung perfusion (EVLP) was adopted in clinical practice to assess the quality marginal donor lungs. Subnormothermic temperatures are use among other solid organs improve biochemical, and immunological parameters. In a rat EVLP model donation after circulatory death (DCD) donors, we tested effect four subnormothermic that could further organ preservation. Warm ischemic...

2015
Aron-Frederik Popov Anton Sabashnikov Nikhil P. Patil Mohamed Zeriouh Prashant N. Mohite Bartlomiej Zych Diana Garcia Saez Bastian Schmack Arjang Ruhparwar Pascal M. Dohmen Matthias Karck Andre R. Simon Alexander Weymann

Lung transplantation remains the gold standard for patients with end-stage lung disease. Nevertheless, the number of suitable donor lungs for the increasing number of patients on the waiting list necessitates alternative tools to expand the lung donor pool. Modern preservation and lung assessment techniques could contribute to improved function in previously rejected lungs. Ex vivo lung perfusi...

2012
Israel L. Medeiros Paulo M. Pêgo-Fernandes Alessandro W. Mariani Flávio G. Fernandes Fernando V. Unterpertinger Mauro Canzian Fabio B. Jatene

OBJECTIVE Experimental studies on lung preservation have always been performed using animal models. We present ex vivo lung perfusion as a new model for the study of lung preservation. Using human lungs instead of animal models may bring the results of experimental studies closer to what could be expected in clinical practice. METHOD Brain-dead donors whose lungs had been declined by transpla...

Journal: :European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery 2014
Diana García Sáez Bartlomiej Zych Prashant N Mohite Andre R Simon

We present the case of a 41-year old patient suffering from end-stage pulmonary hypertension secondary to veno-occlusive disease who underwent implantation of a veno-arterial extracorporeal membrane oxygenator as a bridge to lung transplantation (LTx) due to significant deterioration of myocardial pump and liver function. After 33 days on support, lungs with extended donor criteria were offered...

Journal: :Journal of biomechanics 2006
Amy E Kerdok Mark P Ottensmeyer Robert D Howe

Accurate characterization of soft tissue material properties is required to enable new computer-aided medical technologies such as surgical training and planning. The current means of acquiring these properties in the in vivo and ex vivo states is fraught with problems, including limited accessibility and unknown boundary conditions in the former, and unnatural behavior in the latter. This pape...

Journal: :European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery 2011
Shinji Otani Takahiro Oto Tomokazu Kakishita Kentaroh Miyoshi Shiro Hori Masaomi Yamane Shinichi Toyooka Shinichiro Miyoshi

OBJECTIVES Ex vivo lung evaluation (ex vivo) has been developed as a useful method by which to assess lungs from donation-after-cardiac death (DCD) donors prior to transplant. However, the safety of the ex vivo circulation itself with respect to grafts has not been fully investigated. The aim of this study is to evaluate the effects of the ex vivo circuit using a swine lung transplant model. ...

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