Ewing sarcoma is an aggressive, poorly differentiated neoplasm of solid bone that disproportionally afflicts the young. Despite intensive multi-modal therapy and valiant efforts, 70% of patients with relapsed and metastatic Ewing sarcoma will succumb to their disease. The persistent failure to improve overall survival for this subset of patients highlights the urgent need for rapid translation ...

The outcome of tibial allograft reconstruction after resection of a tumour is inconsistent and has a high rate of failure. There are few reports on the use of tibial allografts in children with open growth plates. We performed 21 allograft reconstructions (16 osteoarticular, five intercalary) in 19 consecutive patients between seven and 17 years of age. Two had Ewing's sarcoma, one an adamantin...

Bone and soft tissue sarcomas of the upper extremities in children are rare, but the practicing pediatric orthopaedist should be aware of their presentation, biology and treatment. This report presents a brief review of the presentation, diagnostic findings and treatment of osteosarcoma, Ewing sarcoma, rhabdomyosarcoma, synovial sarcoma and infantile fibrosarcoma of the upper extremity in the p...

Extraskeletal Ewing’ sarcoma (EES) is a rare soft tissue tumor morphologically indistinguishable from the osseous Ewing’s sarcoma (ES). We report a case of recurrent EES of the breast that, to the best of our knowledge, has rarely been reported. It was initially confused for a cyst on ultrasound. In addition, MRI and breast-specific gamma imaging (BSGI) in our case have complementary value over...

Ewing sarcoma is a primary bone tumor which was originally described by Lucke in 1866 but was defined in such detail by Sir James Ewing in 1921 that it is now associated with his name [1]. This tumor involves the spine primarily in 3.5% to 14.9% r ~ ~ases [2,3]. The review of 22 cases of Ewing Sarcoma of the spine by Pilepich et al in 1981 [4] remains the largest study of this pathology in such...

Ewing sarcoma (ES) is rare in Japanese people, and only 30-40 patients develop the disease annually. To diagnose ES, molecular techniques that aim to detect characteristic fusion genes are commonly used in combination with conventional histological and immunohistochemical examinations. The treatment strategy for ES is characterized by multi-disciplinary collaboration between pediatric oncologis...

An overview of the presentation, clinical and radiographic features, and management of the most common benign pediatric bone tumors will be presented below. Malignant bone tumors (Ewing sarcoma and osteosarcoma) are discussed separately. (See "Clinical presentation, staging, and prognostic factors of the Ewing sarcoma family of tumors" and "Osteosarcoma: Epidemiology, pathogenesis, clinical pre...

Small interfering RNAs (siRNAs) are powerful tools commonly used for the specific inhibition of gene expression. However, vectorization is required to facilitate cell penetration and to prevent siRNA degradation by nucleases. We have shown that diamond nanocrystals coated with cationic polymer can be used to carry siRNAs into Ewing sarcoma cells, in which they remain traceable over long periods...

Background. Ezrin is a membrane-cytoskeleton linker protein that has been associated with metastasis and poor outcomes in osteosarcoma and high-grade soft tissue sarcomas. The prognostic value of ezrin expression in Ewing sarcoma is unknown. Methods. The relationship between ezrin expression and outcome was analyzed in a cohort of 53 newly diagnosed Ewing sarcoma patients treated between 2000 a...

Ewing sarcoma is most commonly a bone tumour which has usually extended into the soft tissues at the time of diagnosis. Exceptionally, this tumour can have an extraskeletal origin. Clinical or imaging findings are non-specific and diagnosis is based on histology. We report a case of an extraskeletal Ewing sarcoma developed in the soft tissues of the abdominal wall in a 35-year-old woman who pre...