Bone marrow cells (BMC) are critical to the expansion of the tumor vessel network that supports Ewing sarcoma growth. BMCsmigrate to the tumor and differentiate into endothelial cells and pericytes.We recently demonstrated that stromal-derived growth factor 1a (SDF-1a) regulates platelet-derived growth factor B (PDGF-B) and that this pathway plays a critical role in bone marrow–derived pericyte...

CEBPB copy number gain in Ewing sarcoma was previously shown to be associated with worse clinical outcome compared to tumors with normal CEBPB copy number, although the mechanism was not characterized. We employed gene knockdown and rescue assays to explore the consequences of altered CEBPB gene expression in Ewing sarcoma cell lines. Knockdown of EWS-FLI1 expression led to a decrease in expres...

Outcomes for patients with metastatic and recurrent Ewing sarcoma remain poor and a better understanding of the biology of this malignancy is critical to the development of prognostic biomarkers and novel therapies. Therefore, the Children's Oncology Group (COG) has created tissue banking protocols designed to collect high quality, clinically annotated, tumor specimens that can be distributed t...

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Primary Ewing sarcoma of the kidney is a very rare neoplasm that generally occurs in young adults. We report a 69-year-old woman with a history of breast cancer who on a routine annual bone scan was found to have a suspicious area over the right kidney. Computed tomography revealed a 16 by 15-cm mass that was removed by a radical nephrectomy. Pathologic examination confirmed the diagnosis of ...

A case of Ewing sarcoma in a 16-year-old girl with 47 XXXc karyotype is reported.

Objetivos: describir el caso de una paciente con antecedente neurofibromatosis tipo 1 que en su evolución natural progresó a sarcoma Ewing. Presentación del caso: se trata 18 años consulta por un cuadro aproximadamente meses evolución, consistente la aparición tumor brazo izquierdo, crecimiento progresivo y doloroso asociado déficit neurológico debido al compromiso nervio ulnar radial. Se inici...

ABSTRACT Background Ewing Sarcoma is the second most frequent primary bone cancer, following Osteosarcoma in children. These tumors consist of small, round, or oval cells, which are believed to derive from parasympathetic autonomic nervous system. The common clinical presentations are pain, local tenderness, fever, palpable mass, and pathologic fractures. Methods and Materials This study de...

Osteosarcoma is the most frequent malignant bone neoplasm, followed by chondrosarcoma and Ewing sarcoma. The diagnosis of bone neoplasms is generally made through histological evaluation of a biopsy. Clinical and radiological features are also important in aiding diagnosis and to complete the staging of bone cancer. In addition to these, there are several non-specific serological or specific mo...

The management of Ewing sarcoma has evolved over the last few decades with successive improvement in survival rates. Multidisciplinary management is the key to successful outcomes. Dose intensity of chemotherapy is of vital importance. Local control can be effectively achieved with surgery, radiation therapy or a combination of the two. The choice of appropriate local therapy should be individu...