The objective of this study was to develop a novel bacterially-triggered micro-particular system of de-esterified tragacanth (DET) in combination with Eudragit S-100 coated capsules for colon drug delivery of 5-fluorouracil (5-FU) using microemulsion method. The loading study was conducted at different drug-to-polymer ratios and cross-linker concentrations. The maximum loading efficiency was ac...

Purpose: To formulate Eudragit RS 100-based nanoparticles containing metronidazole (MTZ NPs) and incorporate them into hydrogels using different gelling agents for controlled release in the buccal mucosa.
 Method: MTZ NPs were fabricated nanoprecipitation method. (1 % w/w) introduced excipients. Physicochemical properties of NPs, mucoadhesive strength spreadability hydrogels, ex vivo perme...

The aim of present study was to improve the solubility Rasagilline mesylate, an Atypical Antipsychotic agent which is BCS Class III drug and thus has very low hence poor bioavailability owing less absorption. Moreover mesylate a bitter taste. Thus in attempt made taste mask oral by formulating into solid dispersion then formulate dispersions Fast Dissolving Tablets. Solid Dispersions were formu...

Objective of present study involves preparation and evaluation of floating microballoons of indometacin as a model drug, to increase its residence time in the stomach without contact with the mucosa. The microballoons were prepared by the emulsion solvent diffusion technique using different ratio of acrylic polymers (Eudragit RS100 and Eudragit S 100) as carriers. The yield of microballoons was...

Coated hard capsules are becoming increasingly important for a number of reasons such as administration of new active ingredients, oral vaccination, colon drug delivery or their use in preclinical and clinical trials. The independency of coating composition on capsules filling is the major advantage of this dosage form. In our study, two types of hard capsules (gelatin and hypromellose) were co...