In recent years, researches on reinforcement learning (RL) have focused on bridging the gap between adaptive optimal control and bio-inspired learning techniques. Neural network reinforcement learning (NNRL) is among the most popular algorithms in the RL framework. The advantage of using neural networks enables the RL to search for optimal policies more efficiently in several real-life applicat...

buccal mucoadhesive films have attracted great attention among mucoadhesive systems due to their ability to adhere and remain on the oral mucosa and to release their drug content gradually. the aim of the current study was to formulate the ziziphus jujuba aqueous extract as buccal bioadhesive film, which continiously releases the drug at sufficient concentration for reducing the frequency of th...

buccal mucoadhesive systems among novel drug delivery systems have attracted great attention in recent years due to their ability to adhere and remain on the oral mucosa and to release their drug content gradually. buccal mucoadhesive films can improve the drug therapeutic effect by enhancement of drug absorption through oral mucosa increasing the drug bioavailability via reducing the hepatic f...

Microcontainers, which are microfabricated cylindrical devices with a reservoir function, have shown promise as an oral drug delivery system for small molecular compounds. However, they never been evaluated against relevant control formulation. In the current study, we prepared microcrystalline cellulose (MCC) microspheres in vitro and vivo testing of SU-8 microcontainers system. Both dosage fo...

E-mail: [email protected] The objectives of the present investigation were: (1) to elucidate the effect of formulation variables e.g., amount of Eudragit RS 100, concentration of Tween 80 and agitation speed on in-vitro release profiles of indomethacin from multiparticulates system, formulated with the combination of ethyl cellulose and Eudragit RS 100 by using a novel quasi emulsion solve...

Hyaluronan-cisplatin conjugate nanoparticles (HCNPs) were chosen as colon-targeting drug-delivery carriers due to the observation that a variety of malignant tumors overexpress hyaluronan receptors. HCNPs were prepared by mixing cisplatin with a hyaluronan solution, followed by dialysis to remove trace elements. The cells treated with HCNPs showed significantly lower viability than those treate...

OBJECTIVE Development of liposomal mucoadhesive drug delivery system, which is able to improve the bioavailability of poorly absorbed oral drugs by prolonging their gastric and intestinal residence time, through facilitating the intimate contact of the delivery system with the absorption membrane. MATERIALS AND METHODS Liposomes containing model drug atenolol were prepared by the modified eth...

Piroxicam (PRX), a potent nonsteroidal anti-inflammatory drug, is prescribed to relieve postoperative and/or chronic joint pain. However, its oral administration often results in serious gastrointestinal adverse effects including duodenal ulceration. Thus, a novel cationic nanoparticle (NP) was explored to minimize the systemic exposure and increase the retention time of PRX in the joint after ...

Insomnia is becoming increasingly prevalent in the world general population. Therapies used by patients include over-the-counter therapies, herbal and dietary supplements, and pharmacological or nonpharmacological treatments. Among these, zolpidem is a pharmacological treatment popularly used for insomnia. Zolpidem is well tolerated and especially efficacious for initiation of sleep, and theref...

The present work was performed to develop and evaluate transdermal patches of combined antiasthmatic drugs (salbutamol sulphate and ketotifen fumarate). Polyvinyl alcohol membrane was used as backing membrane and eudragit RL-100 was used as matrix material to suspend the drugs in the continuous thickness of the patch. Methanol was solvent and propylene glycol was used as plasticizer. Tween 20, ...