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PURPOSE This retrospective study evaluated the clinical and radiographic status of nonsurgical endodontic treatment (ET) of anterior and posterior teeth in HIV-seropositive patients. METHODS ET was analyzed in 26 anterior and 34 posterior teeth from 54 consecutive HIV patients (gender ratio 3 Male : 1 Female, mean age 40.2 years, mean CD4 240, CD4<500 in 88%, 12 with AIDS) over a six year per...

Over the last two decades, the vascular endothelium has been shown to produce a variety of vasoactive substances that are crucial for the regulation of vascular tone, both in health and disease. This concept emerged in 1980, with the discovery of endothelium-derived relaxing factor, later characterized as nitric oxide. In 1985 Hickey et al. reported the existence of a vasoconstricting factor de...

BACKGROUND Endothelin (ET) is a potent vasoconstrictor, and its concentration is increased in patients with heart failure. The purpose of this study was to investigate the role of endothelin in heart failure by use of a rat model. METHODS AND RESULTS Experiments were performed on rats at 1 through 16 weeks after sham operation or coronary artery ligation. Rats with left ventricular end-diasto...