In an attempt to study the involvement of tyrosine kinase pathway in estrogen receptor signaling pathway, we used emodin, a tyrosine kinase inhibitor, to treat MCF-7 cells, a breast cancer cell line which express high level of estrogen receptor protein. Here we reported that emodin inhibited estrogen-induced expression of bcl-2 protein in MCF-7 breast cancer cells. Unexpectedly, treatment of th...

BACKGROUND AND AIMS Although Breast carcinoma had many targeted biomarkers for its treatment, however, it is a heterogeneous disease with different outcomes and need new markers especially for the triple negative group when estrogen receptor, progesterone receptors and Her2/neu are negative. Androgen receptor is a new target with unclear role. The aim of this study was to examine the prevalence...

The term liquid biopsy reveals a non-invasive diagnostic method that might be based on the quantification of cell-free microRNAs in body fluids. However, identification candidates for is challenging. Our aim was to compare expression miR-483-5p, miR-205-5p, and let-7f-5p ovarian cell cultures plasma samples patients with cancer. Both intracellular miR-205-5p proved higher Estrogen Receptor α (E...

Tumor-associated macrophages (TAMs) are the main immune cells in tumor microenvironment (TME) of endometrial cancer (EC). TAMs recruitment and polarization EC is regulated by TME EC, culminating a predominantly M2-like macrophage infiltration. promote lymphatic angiogenesis through cytokine secretion, aid escape synergizing with other cells, contribute to development secretion exosomes so as pr...

Cancer metastasis is largely incurable and accounts for 90% of breast cancer deaths, especially the aggressive basal-like or triple negative (TNBC). Combining patient database analyses functional studies, we examined association integrin family members with clinical outcomes as well their connection previously identified microRNA regulators metastasis, such miR-206 that inhibits stemness TNBC. ...

background: the organochlorine ddt has estrogenic activity but the mechanism underlying the estrogenic activity of this pesticide remains unclear. in the present investigation here, we studied the transcriptional effects of a synthetic organochlorine pesticide o,p’-ddt [1.1.1.-trichloro-2-(o-chlorophenyl)-2-p-chloriphenyl ethane] and its metabolite p,p'-dde (2-2-bis(4/chlorophenyl)-1-1-dic...

the hippocampal system plays an important role in memory function. neurohormones like androgens and estrogens that syntheses in hippocampus have an important role in learning and memory. many biological effects of estrogens in the brain via estrogenic receptors (ers) are investigated. the current research has conducted to assess the effect of estrogenic receptors on spatial discrimination in ra...

background : breast cancer (bc) is the most common cancer in iranian women, meanwhile the iranian patients are relatively young. granzyme h (gzmh) is a functional cytotoxic serine protease of nk cell granules, which expands the cell death-inducing repertoire of innate immune system. gzmh is constitutively and highly expressed in human nk cells, in order to possess chymotrypsin-like (chymase) en...

Numerous epidemiological studies clearly suggest that estrogen is one of the main driving forces in breast tumorigenesis, but precise mechanisms of cancer promotion by estrogen remain poorly understood. Classically, tumorigenic effects of estrogen have been attributed to its ability to directly promote the proliferation of breast cancer cells. In addition to abnormal proliferation, interactions...