Estradiol treatment of ovariectomized rodents is known to affect the morphology of dendritic spines and produce behavioral and cognitive effects. Kalirin-7 (Kal7), a postsynaptic density (PSD)-localized Rho-guanine nucleotide exchange factor, is important for dendritic spine formation and stability. Male Kal7 knockout [Kal7(KO)] mice exhibit a number of abnormal behavioral and biochemical pheno...

An inhibition of vitellogenesis is observed in fish exposed to cadmium (Cd), either in natural or in experimental conditions. To investigate whether this correlates or not with modifications in the expression of several genes involved in reproduction, we have performed a study on juvenile rainbow trout (Oncorhynchus mykiss) exposed to waterborne Cd in combination with estradiol (E2). A relative...

UNLABELLED 17β-Estradiol (E2) treatment limits the pathology associated with pulmonary diseases caused by pathogens, allergens, and asthma, partly by reducing the production of proinflammatory cytokines and chemokines. To test the hypothesis that E2 protects against influenza A virus (IAV) infection by altering the recruitment and activity of innate immune cells and T cells, chemokine concentra...

The steroid 17β-estradiol (E2) is well known to influence hippocampal functions such as memory, affective behaviors, and epilepsy. There is growing awareness that in addition to responding to ovarian E2, the hippocampus of both males and females synthesizes E2 as a neurosteroid that could acutely modulate synaptic function. Previous work on acute E2 actions in the hippocampus has focused on exc...

Studies have shown that hormones endocrine disrupting properties, which characterize them as potentially toxic to the aquatic environment. This study aims monitor water along Prosa Stream/Anhanduí River monthly, evaluate its contamination by 17β-estradiol (E2) and 17α-ethinylestradiol (EE2). Dispersive liquid-liquid microextraction (DLLME) was used for analyte extraction, with acetone a dispers...

background: it is reasonable to think that some biochemical characteristics of follicular fluid (ff) surrounding the oocyte may play a critical role in determining the quality of oocyte and the subsequent potential needed to achieve fertilization and embryo development. objective: this study was carried out to evaluate the levels of ff homocysteine (hcy) in ivf candidate polycystic ovary syndro...

background: the uterus is a dynamic tissue responding to hormonal changes during reproductive cycles. as such, uterine stem cells have been studied in recent years. transcription factors oct4 and sox2 are critical for effective maintenance of pluripotent cell identity. objective: the present research evaluated the mrna expression of oct4 and sox2 in the uterine tissues of ovariectomized mice tr...

Mottino, Aldo D., Fernando A. Crocenzi, Enrique J. Sánchez Pozzi, Luis M. Veggi, Marcelo G. Roma, and Mary Vore. Role of microtubules in estradiol-17 -D-glucuronide-induced alteration of canalicular Mrp2 localization and activity. Am J Physiol Gastrointest Liver Physiol 288: G327–G336, 2005. First published September 16, 2004; doi:10.1152/ajpgi.00227.2004.—Estradiol-17 -D-glucuronide (E2-17G) i...

Administration of 17β-estradiol (E2) has beneficial effects on cognitive function in peri- but not post-menopausal women, yet the molecular mechanisms underlying age-related changes in E2 action remain unclear. We propose that there is a biological switch in E2 action that occurs coincident with age and length of time after ovarian hormone depletion, and we hypothesized that age-dependent regul...

Besides its crucial role in many physiological events, 17β-estradiol (E2) exerts protective effects in the central nervous system. The E2 effects are not restricted to the brain areas related with the control of reproductive function, but rather are widespread throughout the developing and the adult brain. E2 actions are mediated through estrogen receptors (i.e., ERα and ERβ) belonging to the n...