The synthesis and characterization of 1,1,1′1′-tetrapinacolborylethane is conducted to study the functionalization that densely borylated small molecules through Cu-catalyzed coupling with allyl halides. A second allylic alkylation homoallyl triboronate products gave access mixed dihomoallyl diboronates. intramolecular concatenated version produced methylenecyclopentane-1,2-dipinacolboronic est...

A facile, high yielding synthesis of 9,10-dihydro-9,10-ethano- anthracene-11- carboxylic acid methyl ester using a modified commercial domestic microwave oven is reported.

Ko143 is a tetracyclic, synthetic analog of the fungal metabolite fumitremorgin C. potent and specific inhibitor membrane-bound efflux transporter ABCG2, it reverses ABCG2-mediated drug resistance in cancer cells. Here, we describe an improved synthesis that relies on highly selective, substrate-controlled reduction imine formed Bischler–Napieralski reaction with amide derived from 6-methoxy-l-...

Marinobacter hydrocarbonoclasticus DSM 8798 has been reported to synthesize isoprenoid wax ester storage compounds when grown on phytol as the sole carbon source under limiting nitrogen and/or phosphorous conditions. We hypothesized that isoprenoid wax ester synthesis involves (i) activation of an isoprenoid fatty acid by a coenzyme A (CoA) synthetase and (ii) ester bond formation between an is...

The present invention provides a process for the synthesis of an α,β-unsaturated ester from a mono-olefinester using Fe(CO).sub.5.

Several diesters were prepared from commercially available oleic acid and common organic acids. The key step in the three step synthesis of oleochemical diesters entails a ring opening esterification of alkyl 9,10epoxyoctadecanoates (alkyl: propyl, isopropyl, octyl, 2ethylhexyl) using propionic and octanoic acids without the need for either solvent or catalyst. Each synthetic diester was evalua...

Dietary orotic acid is known to cause impaired fatty acid synthesis and increased cholesterol synthesis in rats. We found that the impaired fatty acid synthesis occurs during the first day of orotic acid feeding and, in studies with albumin-bound [1-14C]palmitic acid, an associated decrease in the rate of esterification of this fatty acid into triacylglycerol, phospholipid, and cholesteryl este...

A series of linear and macrocyclic peptides 3-12 were synthesized using 3,5-pyridinedicarboxylic acid (1) as starting material and screened for their antimicrobial, anti-inflammatory and anticancer activities. Bis-ester 3 was prepared from 1 and L-leucine methyl ester. Hydrazinolysis and hydrolysis of dipeptide methyl ester 3 with hydrazine hydrate or 1 N sodium hydroxide afforded compounds 4 a...

Introduction: [18F]-6-thia-14-fluoro-heptadecanoic acid 3b, a free fatty acid, has been used in myocardial PET imaging. In order to establish an automated synthesis module for routine production in the country, a study performed for optimization of the production conditions as well as making modifications. Methods: [18F] Benzyl-14-Fluoro-6-thia-heptadecanoate 2b was prepared in no-carrier...

In Swiss 3T3 fibroblasts bradykinin stimulated inositol phosphate (InsP) formation and prostaglandin E2 (PGE2) synthesis. The EC50 values for stimulation of PGE2 synthesis and InsP formation by bradykinin were similar, 200 pM and 275 pM, respectively. Guanosine-5'-[gamma-thio]triphosphate stimulated PGE2 synthesis and InsP formation, and guanosine-5'-[beta-thio]diphosphate inhibited both PGE2 s...