The regulation of the intracelluar pH (pHi) during spreading of human neutrophils was studied by a combination of fluorescence imaging and video microscopy. Spreading on adhesive substrates caused a rapid and sustained cytosolic alkalinization. This pHi increase was prevented by the omission of external Na+, suggesting that it results from the activation of Na+/H+ exchange. Spreading-induced al...

The aims of this study were to determine the relations between platelet free calcium concentrations ([Ca2+]i), intracellular pH (pHi), and aggregation and to assess the effects of angiotensin II (Ang II) and endothelin-1 on these platelet parameters in normotensive subjects and hypertensive patients. Seventeen normotensive subjects, 25 untreated hypertensive patients, and 34 treated hypertensiv...

In this paper, we define new subclasses ${S}^{*}_{q}(alpha,Phi),$ ${M}_{q}(alpha,Phi)$ and ${L}_{q}(alpha,Phi)$ of analytic functions in the space of logistic sigmoid functions based on quasi--subordination and determine the initial coefficient estimates $|a_2|$ and $|a_3|$ and also determine the relevant connection to the classical Fekete--Szeg"o inequalities. Further, we discuss the improved ...

In this paper we address the issue of uniformly positive scalar curvature on noncompact 3-manifolds. In particular we show that the Whitehead manifold lacks such a metric, and in fact that R3 is the only contractible noncompact 3-manifold with a metric of uniformly positive scalar curvature. We also describe contractible noncompact manifolds of higher dimension exhibiting this curvature phenome...

Most mitochondrial proteins are synthesized in the cytosol and imported into mitochondria. The N-terminal presequences of mitochondrial-precursor proteins contain a diverse consensus motif (phi chi chi phi phi, phi is hydrophobic and chi is any amino acid), which is recognized by the Tom20 protein on the mitochondrial surface. To reveal the structural basis of the broad selectivity of Tom20, th...

We deal with the Sobolev space theory for stochastic partial differential equation (SPDE) driven by Wiener processes $$\begin{aligned} \partial _{t}^{\alpha }u=\left( \phi (\varDelta ) u +f(u) \right) + _t^\beta \sum _{k=1}^\infty \int _0^t g^k(u)\,dw_s^k, \quad t>0, \,x\in {\mathbb {R}}^d \end{aligned}$$ as well SPDE space-time white noise ^{\alpha }_{t}u=\phi )u f(u) ^{\beta -1}_{t}h(u) {\dot...

K-essence is a minimally-coupled scalar field whose Lagrangian density $\mathcal{L}$ function of the value $\phi$ and kinetic energy $X=\frac{1}{2}\partial_\mu\phi\partial^\mu\phi$. In thawing scenario, frozen by large Hubble friction in early universe, therefore initial conditions are specified. We construct k-essence models generating Taylor expansion coefficients $\mathcal{L}(\phi, X)$ from ...

We show that a small neighborhood of a closed symplectic submanifold in a geometrically bounded aspherical symplectic manifold has nonvanishing symplectic homology. As a consequence, we establish the existence of contractible closed characteristics on any thickening of the boundary of the neighborhood. When applied to twisted geodesic flows on compact symplectically aspherical manifolds, this i...