OBJECTIVE To investigate correlations among A-kinase anchor protein95 (AKAP95), Connexin43 (Cx43), CyclinE1 and CyclinD1 in esophageal squamous cell cancer tissues, and their relationship with clinical and pathological parameters. METHODS The protein levels of AKAP95, Cx43, CyclinE1 and CyclinD1 in 54 cases of esophageal squamous cell cancer tissues were determined by immunohistochemistry. ...

Introduction: Esophageal cancer is a common gastro intestinal malignancy. One of the most common techniques of surgery in esophageal cancer is transhiatal esophagectomy with esophagogastric anastomosis in the neck. This technique is accompanied by complications like chronic gastero-esophegeal reflux and late stenosis. This study was designed to compare the risk of complications after two surgic...

Esophageal cancer is one of the most frequently occurring cancers in the world. Targeting therapy strategy of cancer with specific inhibitors is developing and has showed promising antitumor efficacy. It is known that mTOR is an important controller of cell growth. RAD001 (everolimus) is a specific inhibitor of mTOR that can block the mTOR signaling pathway. The purposes of this study was to ex...

Patients with esophageal cancer each year can reach 400,000 people. Inefficient screening methods and worsening symptoms, patients often come late. Squamous cell carcinoma, which is the cause of cancer, has percentage 84% all incidences. So far, current strategy endoscopy biopsy. This main side effect bleeding in metaplastic area. Cellulose Sponge, Detector Esophageal Cancer (CaSPER), be used f...

cancer is a group of diseases characterized by uncontrolled proliferation of abnormal cells. because of the severe side effects and resistance to the traditional chemotherapeutic agents, the necessity for discovery of new anticancer drugs is a crucial topic. in the present study we synthesized new derivatives of 2-(4-fluorophenyl)- n -halophenylacetamide and assessed their cytotoxicity against ...

Background Recent studies revealed that tumor-associated macrophages (TAMs) play a decisive role in the regulation of tumor progression by manipulating tumor oncogenesis, angiogenesis and immune functions within tumor microenvironments. Signal transducer and activator of transcription 3 (STAT3), which is a point of convergence for numerous oncogenic signalling pathways, is constitutively activ...

apoptosis, or programmed cell death, is an essential physiological process that plays a critical role in development and tissue homeostasis. caspases, a family of cysteine-dependent aspartate-directed proteases, play a critical role in the initiation and execution of apoptosis. in this study, cytotoxicity and apoptogenic effect of 2-phenyl 4-carboxamide derivatives were evaluated in sknmc (huma...

normal 0 false false false en-us x-none ar-sa microsoftinternetexplorer4 aim : the present study aimed to investigate the influence of histological factors on survival of patients with esophageal cancer. background : esophageal cancer is almost the common form of malignancy in the eastern world. patients and methods : through a retrospective cohort study a consecutive series of 134 patients wit...