Treatment with solvent/detergent is a widely used method for ensuring the virus safety of plasma products. In the present study, virus inactivation by a novel solvent/detergent combination, i.e. TnBP (tri-n-butyl phosphate) and polysorbate 20 during the manufacture of the factor VIII/VWF concentrate Optivate has been investigated. The inactivation of most enveloped viruses was rapid, i.e. > 5 l...

  Background: Factor VII concentrates are used in patients with congenital or acquired factor VII deficiency or treatment of hemophilia patients with inhibitors. In this research, immunoaffinity chromatography was used to purify factor VII from prothrombin complex (Prothrombin-Proconvertin-Stuart Factor-Antihemophilic Factor B or PPSB) which contains coagulation factors II, VII, IX and X. The a...

Despite the recapitulative nature of bone, a large percentage of nonunions still occur. Many exogenous substances have been administered to aid in the arthrodesis process, yet few have proven efficacious relative to time and cost. With recent advancements in bone biology involving cellular and molecular signaling, it is now possible to selectively retain bone progenitor cells from a patient’s b...

effect of different ratios of sucrose to fruit concentrate (orange and sour cherry), level of cacl2 (0-2%) and storage time (0-90 days) on physicochemical properties of candied apples were investigated using of a combined design. different quality indices such as total sugars content, ascorbic acid, color attribute (chroma) and overall acceptance were modeled and then multiobjective optimizatio...

background: factor vii concentrates are used in patients with congenital or acquired factor vii deficiency or treatment of hemophilia patients with inhibitors. in this research, immunoaffinity chromatography was used to purify factor vii from prothrombin complex (prothrombin-proconvertin-stuart factor-antihemophilic factor b or ppsb) which contains coagulation factors ii, vii, ix and x. the aim...

Background: Recently the role of platelets in the tissue regeneration, wound healing and prevention and control of infections has been reported. We aimed to assess the antimicrobial effect of human platelet concentrate against six bacteria, commonly found in wound and hospital-acquired infections. Methods: In vitro susceptibility to samples of 10 random human platelet concentrates was determin...

The recovery of high-quality, valuable end products from cheese whey is a very important industrial process. The aim of this study is to improve the recovered protein content of concentrate stream in cheese whey. The experiments were conducted by using ceramic ultrafiltration (UF) membrane followed by diafiltration (DF) process with a 15kDa molecular weight cut-off (MWCO). The volume concentrat...

background: recently the role of platelets in the tissue regeneration, wound healing and prevention and control of infections has been reported. we aimed to assess the antimicrobial effect of human platelet concentrate against six bacteria, commonly found in wound and hospital-acquired infections. methods: in vitro susceptibility to samples of 10 random human platelet concentrates was determine...