Abstract Although the causes of depression include a wide range conditions, from neurodegenerative to thyroid, they all have one common denominator, changes in brain. Depression can be located multiple brain regions simultaneously, which may derived molecular abnormality found neurons many regions. Abnormalities receptors or impulse transmission could answer. In this work, simple and accurate s...

Considering the heterogeneous character of depression, it seems likely that many brain regions are involved mediating the diverse symptoms of depression. For example, the mesolimbic DA system has a central function for motivational behaviors and pleasure seeking, and it is possible that malfunctioning of brain reward systems could be an underlying mechanism of the anhedonia experienced in depre...

BACKGROUND Alcohol dependence comorbid with major depressive disorder poses a major challenge in the clinical setting. The results in the treatment with selective serotonin re-uptake inhibitors have been conflicting. Thus, we compared in alcohol-dependent patients with co-morbid major depressive disorder the selective serotonin re-uptake inhibitor escitalopram to a compound that acts on differe...

Introduction: Depression can present with several symptoms, such as loss of pleasure, feelings guilt, low selfesteem, and disturbed sleep or appetite. In recent socio- economic scenario incidence & prevalence depressionis on increasing trend. SSRIs are the mainstay treatment depression.Objective: anti-inflammatory role escitalopram in freshly diagnosed depression case also to find anycorrel...

A new, simple, fast and reliable zero order spectrophotometric method has been developed for determination of Escitalopram Oxalate in bulk and tablet dosage forms. The quantitative determination of drug was carried out using the zero order values (absorbance) measured at 238 nm. Calibration graph constructed at 238 nm was linear in concentration range of 2-20 µg/ml with correlation coefficient ...