نتایج جستجو برای: erythrocytosis
تعداد نتایج: 780 فیلتر نتایج به سال:
Detection of the JAK2V617F mutation is of major help in the diagnosis of myeloproliferative neoplasms (MPNs). Techniques using allele-specific quantitative PCR (AS-qPCR) can reliably and consistently detect down to 0.001% mutated alleles. Moreover, a study of healthy blood donors has shown that the maximum JAK2V617F value in 200 subjects was 0.035%. In practice, a positivity threshold of 1% is ...
Erythropoietin (Epo) binding to the Epo receptor (EpoR) elicits downstream signaling that is essential for red blood cell production. One important negative regulatory mechanism to terminate Epo signaling is Epo-induced EpoR endocytosis and degradation. Defects in this mechanism play a key role in the overproduction of erythrocytes in primary familial and congenital polycythemia (PFCP). Here we...
Secondary polycythaemia results from increased Erythropoietin production which acts on normal erythropoietic progenitors leading to erythrocytosis. This report is about a 64 years old hypertensive and anaemic male who presented with complaints of painful per rectal bleeding dribbling micturition. On undergoing relevant investigations, he was found be low haemoglobin haematocrit. Lateron, subseq...
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