Cytochrome P450 1A1 (CYP1A1) is a heme-containing mono-oxygenase involved in metabolism of environmental contaminants. Two variants of dog CYP1A1 with a single residue difference were identified and designated Sap1 and Sap2. Compared with Sap1, Sap2 had a Trp50Leu substitution. The biochemical characteristics of the variants were comparatively analyzed using heterologous expression in Escherich...

In the disturbed Baltic Sea ecosystem, several animal species display failing health related to exposure toxic compounds, reduced energy metabolism and immune system disorders. order investigate possible associations between fish chemicals affecting defence, levels of algal toxins (bromophenols, hydroxylated polybrominated diphenyl ethers nodularin), perfluorinated alkyl substances (PFAS) thiam...

Body mass, fork length, RNA:DNA ratio, specific growth rate, and hepatic EROD activity and CYP1A expression, were measured in three-spined sticklebacks in the River Ray (south west England) at sites downstream of an urban waste water treatment works (WWTW) prior to, and following, remediation of the effluent with granular activated carbon (GAC) tertiary treatment. During the same two-year perio...

Title of Document: EFFECTS OF PCB EXPOSURE ON HEPATIC GENE EXPRESSION AND ENZYME ACTIVITY IN AVIAN SPECIES Meredith E. Bohannon, Doctor of Philosophy, 2014 Directed By: Professor M.A. Ottinger, Department of Animal and Avian Sciences Polychlorinated biphenyls (PCBs) are a class of anthropogenic chemical compounds used by industry from the 1940s until the 1970s. Two General Electric plants at Fo...

chemicals and ionizing radiation. While an earlier study by other researchers did not find any correlation between increased placental UGT activity and maternal cigarette smoking, this study found a strong correlation for mothers who were both drug abusers and smokers. This suggests that illicit drugs compound the problems associated with smoking. The study also reports the discovery of a previ...

Port Phillip Bay, Australia, is a large semi-closed bay with over four million people living in its catchment basin. The Bay receives waters from the Yarra River which drains the city of Melbourne, as well as receiving the discharges of sewage treatment plants and petrochemical and agricultural chemicals. A 1999 study demonstrated that fish inhabiting Port Phillip Bay showed signs of effects re...

Abstract Background In Germany and the EU, most headwaters are still far from reaching a good chemical ecological status as it is required by European Water Framework Directive (WFD), until 2027 latest. Particularly, in densely populated areas, impacts municipal industrial wastewater discharges or diffuse agricultural emissions matter of concern. This also applies to Nidda River which considere...