Thirty six fine needle aspirates from various types of benign breast lesions were examined by electron microscopy and correlated with their cytological appearances. In all cases the parenchyma consisted of clumps of cohesive cells with the ultrastructural features of epithelial cells. In many cases, particularly from fibroadenomas, the parenchyma consisted of single layers of polarised epitheli...

UNLABELLED A history of a recent rapid increase in long-standing swelling mass was presented in the right parotid gland of an 85-year-old male. The inadequate cytologic specimens contained few small clusters of three-dimensional malignant epithelial cells having hyperchromatic pleomorphic nuclei and prominent nucleoli, adjacent to a cluster of benign monomorphic myoepithelial cells. We first in...

blastoma is appropriate. In the present case, clinical uncertainty regarding cellular composition coupled with progressive proptosis and its associated corneal complication prompted debulking of the lesion. The history of metastatic neuroblastoma and the presence of multiple ganglioneuromas lend credence to the theory purporting the presence of rests of metastatic neuroblastoma that subsequentl...

INTRODUCTION Soft tissue myoepithelial carcinoma and myoepithelioma are rare entities, part of myoepithelial tumors. They were incorporated into the World Health Organization classification of soft tissue tumors in 2002. Here we present an exceptional case of myoepithelial carcinoma and myoepithelioma association. To the best of our knowledge, such an association has never been reported in the ...

INTRODUCTION Infiltrating myoepithelial carcinoma remains a rarely encountered lesion of the breast. The few cases that have surfaced firmly document the histopathology of this tumor, but its cytologic characteristics seemingly have been described in only one other report. CASE PRESENTATION Here we present the cytologic findings from a case of infiltrating myoepithelial carcinoma of the breas...

We describe a 74-year-old woman with no family history of breast cancer who presented with a high-grade myoepithelial carcinoma. Diagnosis was supported by immunohistochemical staining for both epithelial (ie, keratin) and myoepithelial (eg., p63, S-100, actin) differentiation. Because the patient reported that her family had an extensive history of neoplasm, a genetic study was ordered. To our...

PURPOSE This study investigated the functional and clinical significance of integrin αvβ6 upregulation in myoepithelial cells of ductal carcinoma in situ (DCIS). EXPERIMENTAL DESIGN Archival samples of DCIS and DCIS with associated invasion (n = 532) were analyzed for expression of αvβ6 by immunohistochemistry and ability to predict recurrence and progression assessed in an independent, uniqu...

BACKGROUND Carcinosarcoma of the salivary glands is a rare neoplasm, and the minimally invasive form constitutes a subgroup with a more favorable prognosis. The cytomorphologic features of this neoplasm can be appreciated on fine-needle aspiration biopsy. METHODS AND RESULTS We present a patient with a minimally invasive carcinosarcoma ex non-recurrent pleomorphic adenoma (Ca ex PA) who under...

objective: e-cadherin is a classic cadherin that plays a key role in epithelial cell adhesion. this protein is being referred to as the suppressor of proliferation and invasion. limited studies have investigated e-cadherin expression in salivary gland neoplasms. this study sought to assess the expression of e-cadherin and its possible role in progression and invasion of salivary gland neoplasms...