objective: acinetobacter baumannii (a. baumannii) has a good potential to colonize on various surfaces. as a virulence factor, adhesion to surfaces is the first step in colonization. the two-partner secretion system (tps) proteins are key factors for bacterial attachment. the purpose of this study is to identify and study the role of this family of proteins in adhesion of a. baumannii to human ...

Krox20, a zinc finger-containing transcription factor, is well known for mediating stem and progenitor cell activation differentiation in variety of tissues. In recent study, we reported the first time population epithelial-derived Krox20-expressing keratinocytes hair follicle that ultimately terminally differentiate to form structural component shaft. These Krox20-lineage cells also mediate me...

a new series of 1,2-diaryl-4,5,6,7-tetrahydro-1h-benzo[d]imidazoles, possessing trimethoxy phenyl pharmacophore, were synthesized to evaluate their biological activities as tubulin inhibitors. cytotoxic activity of the synthesized compounds 7a-f was assessed against several human cancer cell lines, including mcf-7 (breast cancer cell), hepg2 (liver hepatocellular cells), a549 (adenocarcinomic h...

two set of 2-aryl-5,6-dihydropyrrolo[2,1-a] isoquinolines were designed and synthesized to evaluate their biological activities as topoisomerase inhibitors. cytotoxic activity of the synthesized compounds 4a-e and 7a-d was assessed against several human cancer cell lines, including mcf-7 (breast cancer cell), hepg2 (liver hepatocellular cells), a549 (adenocarcinomic human alveolar basal epithel...

Epithelial to Mesenchymal Transition The cover image shows that the malignant cells generated by epithelial-mesenchymal transition (EMT) are breaking away from benign ones and spreading elsewhere. In article number 2106498, using single-particle tracking of β1-integrins labelled with fluorescent quantum dots, Yan Wei, Peng-Ye Wang, Hui Li, co-workers discover a significantly enhanced diffusion ...

Background: Ovarian cancer is the fifth leading cause of death from malignancy in women. CD4 +CD25+FoxP3+ regulatory T (Treg) cells are a subset of T lymphocytes with great inhibitory impact on immune response. Objectives: To investigate the percentage of CD4 +CD25+FoxP3+ regulatory T cells in the peripheral blood of the Iranian patients with epithelial ovarian cancer compared to healthy women ...

A multimodal proteomic analysis of the perturbations that SARS-CoV-2 and SARS-CoV induce in infected human lung epithelial cells reveals common distinct immune-evasive pathobiological mechanisms used by these coronaviruses.

High-risk human papillomaviruses (HPVs) infect epithelial cells and induce viral genome amplification upon differentiation. HPV proteins activate DNA damage repair pathways by inducing high numbers of breaks in both cellular DNAs.

purpose: to characterize the histopathologic, electron microscopic and confocal scan features of ahram mineral water (amw)-induced keratopathy in cadaver corneas. methods: seven cadaver globes were examined, five of which were exposed to amw from the corneal side for different durations (30 seconds, 3, 15, 30, and 60 minutes) and the other two were considered as controls. after performing confo...