Vasodilator prostaglandin PGE(2) protects the kidney from excessive vasoconstriction during contraction of extracellular fluid volume and pathophysiological states. However, it is not yet clear which of the four known E-prostanoid (EP) receptors is localized to resistance vessels and mediates net vasodilation. In the present study, we assessed the presence, signal transduction, and actions of E...

Prostaglandin E(2) (PGE(2)), an important mediator of the inflammatory response, acts centrally to elicit sympathetic excitation. PGE(2) acts on at least four E-class prostanoid (EP) receptors known as EP(1), EP(2), EP(3), and EP(4). Since PGE(2) production within the brain is ubiquitous, the different functions of PGE(2) depend on the expression of these prostanoid receptors in specific brain ...

BACKGROUND AND AIMS Involvement of prostaglandin E(2) (PGE(2)) receptors EP(1), EP(2), and EP(4) in the formation of aberrant crypt foci (ACF) and/or intestinal polyps has been suggested. In contrast, EP(3) appears to have no influence on the early stages of colon carcinogenesis. In the present study, we examined expression of PGE(2) receptor subtypes EP(1), EP(2), EP(3), and EP(4) in normal co...

PURPOSE To investigate the effect of indomethacin inhibition of prostanoid production on the epinephrine-stimulated increase in outflow facility and cyclic adenosine monophosphate (cAMP) production in the anterior segment of the monkey eye. METHODS Topical indomethacin was given 1 hour before the intracameral administration of epinephrine to living cynomolgus monkeys. Outflow facility was mea...

introduction: various hemostatic and analgesic agents and techniques have been used to reduce intraoperative and postoperative hemorrhage and pain in tonsillectomy.aims and objective; the current study aimed to compare the effect of using adrenaline plus tramadol and normal saline in maintaining hemostasis and control of pain in cold dissection tonsillectomy.   materials and methods: this prosp...

background: hemoptysis occurs due to either pulmonary diseases or bronchoscopy interventions. the aim of the present study was to compare the efficacy of the endobronchial instillation of adrenaline with that of tranexamic acid. methods: fifty patients were randomly selected as 2 double-blinded sample groups (n=25). in these patients, bleeding could not be controlled with cold saline lavage dur...

Anaphylaxis is a potentially deadly condition that requires emergent therapy. While frequently treated in the emergency department (ED), recent evidence updates may improve diagnosis and management of this condition. This paper evaluates key evidence-based concerning anaphylaxis for clinician. The presentation can vary. Current diagnostic criteria be helpful when evaluating patients anaphylaxis...

BACKGROUND Hemangioma is the most common tumor of neonatal period and it is almost always appeared by the end of the first week of life and can be found mostly in head and neck area. This study evaluated the synergistic effect of bleomycin, triamcinolone and epinephrine in treatment of hemangioma and arte-riovenous malformations. METHODS In this multicenter study, a combination of bleomycin,...

Background & Aim: This experiment was conducted to examine the effect of different levels of Echinacea purpurea (EP) in comparison with an antibiotic (flavofosfolipol) on total antioxidant activity (AOA) in serum of broiler chicks. Experimental: In this trial 240 one-day-old broiler chicks (Ross 308) were weighed and randomly assigned to the 5 treatment groups, each with 4 re...