The effect of intra-arterial and intravenous epinephrine on skeletal muscle blood flow and metabolism were studied in the human forearm following complete suppression of the circulation to forearm skin by epinephrine iontophoresis. Epinephrine by either route of administration increased blood flow, O., consumption and CO;> production, and decreased arteriovenous differences of O., and CO2 acros...

(Log dose)-response curves have been determined for lipolysis and for the conversion of glucose-(14)C to (14)CO(2) by adipose tissue from rats in the presence of epinephrine, corticotropin, and thyrotropin. The stimulatory effect of epinephrine on lipolysis was greater than that of corticotropin or thyrotropin. Lipolysis induced by epinephrine was inhibited by propranolol but only slightly by p...

Changes in the plasma free fatty acids of a pancreatectomized subject and in free fatty acids and insulin in 10 normal subjects in response to the in vivo infusion of epinephrine alone, epinephrine plus phentolamine, and epinephrine plus propranolol indicate that both alpha and beta adrenergic receptors are present in human adipose tissue. Under the experimental conditions used, adipose tissue ...

The effect of specific electrolyte changes and of desoxycorticosterone on the responsiveness of vascular smooth muscle to epinephrine was studied using rabbit aortic strips. Low sodium increases, while high sodium decreases the epinephrine response. Conversely, low potassium decreases, while high potassium increases the epinephrine response. Desoxycorticosterone potentiates the epinephrine resp...

Results 78 paediatric and 74 adult cases were reported. Two deaths occurred. Personnel and emergency centres involved in the management were known in 147 cases, and treatment in 136 cases. First-aid was provided at home by patients themselves on 43 occasions or by the family physician 12 times. 49 called for an ambulance. 89 required hospitalisation in an Emergency Department. Epinephrine auto-...

Epinephrine 2% drops were administered to one eye and a placebo to the fellow eye twice a day for 2 weeks in 18 normal human volunteers. The circadian rhythm of aqueous humor flow was measured by fluorophotometry. Epinephrine (compared with placebo) had no measurable effect on the rate of aqueous flow or the circadian rhythm of aqueous humor flow. These results suggest either that topical appli...

BACKGROUND While epinephrine is the recommended first-line therapy for the reversal of anaphylaxis symptoms, inappropriate use persists because of misunderstandings about proper dosing and administration or misconceptions about its safety. The objective of this review was to evaluate the safety of epinephrine for patients with anaphylaxis, including other emergent conditions, treated in emergen...

Timely and proper injection of epinephrine is critical to prevent serious consequences relating to anaphylaxis. In a recent bioavailability study comparing epinephrine delivery from the Auvi-Q™ and EpiPen(®) epinephrine autoinjectors, the Auvi-Q failed to meet the bioequivalence threshold when using partial area under the curve (AUC) analyses based on zero to Tmax recommended for highly variabl...

Anaphylaxis is a serious clinical condition that can affect all ages and many systems (skin, gastrointestinal system, respiratory and cardiovascular systems). There are a few case reports of cardiac and cerebrovascular complications due to the anaphylaxis and/or the treatment with epinephrine. A 69-year-old female patient with known coronary artery disease (CAD), coronary artery bypass graft (C...

Hemin is an activator of heme oxygenase-1 (HO-1), enzyme catalyzing degradation. Up-regulation HO-1 observed in response to various pathological conditions. Moreover, pharmacological activation associated with numerous beneficial effects the organism. was shown exert, among other, anti-diabetic and anti-obesity properties. These are strongly linked adipose tissue. However, direct influence hemi...