50 years are an extended epoch to consider for developments in epileptology. Th erefore only a selection of important milestones can be covered with regard to available space. After looking back to the past current activities and important aspects for future research will be discussed. Concerning epidemiology one of the fi rst important studies investigated the role of precipitation of epilepti...

The recognition of epilepsy syndromes and attempts at their classi®cation has led to a burgeoning literature in this area. This body of research represents one of the most important advances in epileptology over the last 20 years. The addition of neuroradiological insights and, more recently, genetic discoveries have both enhanced our ability to diagnose and classify epilepsy syndromes and to u...

Seizures in the neonatal period are serious events associated with high morbidity and mortality. A major clinical problem is that neonatal epileptic seizure activity shows only limited response to the commonly used anticonvulsant drugs. Consequently, the optimal treatment of neonatal seizures (NSs) is currently a highly prioritized issue (Silverstein et al., 2008). There is not only a lack of w...

how to cite this article: inaloo s, katibeh p. an epidemiologic study of 389 children with epilepsy in southern iran.iranian journal of child neurology2011;5(4):15-20 objective approximately 4% of the world's population experience one or more febrile seizures during their lifetime, and 0.5-1% of the population has active epilepsy.less than one-third of the reported seizures are categorized as e...

Objectives: The aim of this study was to investigate the antiepileptic drug (AED) treatment of adults suffering from focal epilepsies (FE) in Germany. Of special interest was the number and percentage of the patients 16 years and older receiving no treatment with an AED, treatment with one AED (monotherapy), treatment with more than one AED, and treatment with a novel AED. The definition for "n...

Sir Victor Horsley, a British neurosurgeon, pioneered epilepsy surgery and, in 1886, published the reports of successful cortical resections that resulted in a significant reduction in epileptic seizures in three patients (Horsley, 1886). At that time, V. Horsley assisted by J.H. Jackson (epileptologist) and D. Ferrier (neurophysiologist), identified the region to be resected by the location of...

The study by Fauser and colleagues on subtypes of focal cortical dysplasia (FCD) and their impact on post-surgical outcome in focal epilepsies (Fauser et al., 2004) focussed on reports of milder forms of FCD, i.e. focal cortical dysplasia type I (Type 1-FCD) and mild malformations of cortical development (mMCD) according to a recent classification system (Palmini et al., 2004). These entities w...

After the pioneering work of Hans Berger in the 1930s (1), electroencephalography (EEG) opened a new window on epilepsy. This led to its general acceptance and now widespread use. It provided an invaluable new dimension to the ability to locate epileptogenic abnormalities in patients with focal or partial epilepsy. The presence of structural lesions in patients with partial epilepsy had, of cou...

Th ere are moments when you get caught and surprised, and when you do not realize that something has happened. First, you do not believe it because it is not meaningful and it is not fair, but then, you become aware that there is something beyond that you’re not able to control. I guess destiny, as a warning, you should recognize. Two nights ago, the heart of our Smajo stopped knocking. Th ey s...

The general idea of nonstationarity of brain activity or dependence of the dynamics on some, potentially unobserved, temporally changing or fluctuating parameter, has been familiar in the neuroscience community in contexts such as sleep dynamics or epileptology for a long time. However, recently it has been attracting increasing attention in the context of functional brain network analysis. Thi...