The effects of Tahitian noni juice (TNJ), vitamin C and vitamin E on male reproductive functions in cyclophosphamide-treated wistar rats were compared. Thirty five male wistar rats with mean body weight of 180 ± 24.3 g were randomly divided into five groups. Group one were treated with cyclophosphamide (50 mg/kg, i.p.) while, group two were treated with TNJ (10 ml/kg, i.p.) and cyclophosphamide...

Mucuna pruriens Linn., a leguminous plant, has been recognized as an aphrodisiac and spermatogenic agent. Protective efficacy of M. pruriens on reactive oxygen species (ROS)-induced pathophysiological alterations in structural and functional integrity of epididymal sperm in aged Wister albino rat was analysed. Animals were grouped as groups I, II, III and IV, i.e. young (control), aged, aged tr...

Reproductive toxicity of 2-bromopropane (2BP), a substitute for ozone layer-depleting chloro-fluorocarbon, was found among the workers in an electronics factory in Korea in 1995. Furthermore the importance of testicular toxicity has been realized since the problem of endocrine disruptors arose all over the world, but manual methods must rely on subjective assessment. Recently, computer-assisted...

Background Nonyl phenol (NP) has been considered an endocrine disrupting substance causing reproductive dysfunction and increase in reactive oxygen species production in different organs including testis. vitamin E (VitE) is a potent scavenger of free radicals and is able to prevent the membrane damage mediated by free radicals The aim of this study was to elucidate the protective effects of Vi...

The aim of the study was to investigate the effect of 3 primarily COX-1 inhibiting non-steroidal anti­ inflammatory drugs (aspirin, ibuprofen or indomethacin) on rat sperm hyperactivation in vitro. Rat cauda epididymal sperm were continuously incubated with different concentrations of drugs (aspirin: 0.87,1.7 or3.4 mmol; ibuprofen; 0.75,1.5 or 3.0 mmol; and indomethacin; 0.43, 0.87, or 1.7 mmol...

This study aimed to investigate the antifertility effect of Juniperus sabina fruit on male rats and its possible mechanism, and hence it might be developed as a potential nonhormonal male contraceptive. Male rats were intragastrically fed for consecutive 8-week and 4-week recovery with the fruit of J. Sabina, and sperm maturation, serum testosterone level, and histopathology were analyzed. Epid...

Studies on the beneficial effects of vitamins E and D supplementation on functions of caput and cauda epididymides, their spermatozoa, vas deferens and seminal vesicle of sodium fluoride (NaF) treated (10 mg/kg body weight) male mice (Mus musculus) were carried out. The NaF treatment resulted in significant decrease in the body and epididymis weight but those of vas deferens and seminal vesicle...

background: testis tissue xenografting and the resultant sperm in a xenograft may provide a unique approach to rescue the genetic material of males that die prematurely and is a model for the study of human spermatogenesis and can represent an alternative approach for fertility preservation in cancer patients. this study was aimed to evaluate the xenogenic dog sperm in formation of male pronucl...