PURPOSE To investigate whether inhalation of ethyl pyruvate (EP) encapsulated with poly(ethylene glycol)-block-lactide/glycolide copolymer nanoparticles (EP-NPs) can prevent the development of shunt-flow-induced hyperkinetic pulmonary arterial hypertension (PAH) in a rat model. MATERIALS AND METHODS Rats were separated into five groups: blank (ie, no treatment after shunt flow), normal contro...

Erythropoietin (EP) mRNA was measured in normal and anemic mice during fetal and postnatal development. Normal fetal livers at 14 d of gestation contained a low level of EP mRNA. By day 19 of gestation, no EP mRNA was detected in normal or anemic fetal livers or normal fetal kidneys, but anemic fetal kidneys had low levels of EP mRNA. Newborn through adult stage mice responded to anemia by accu...

Objective Cyclophosphamide (CP) is a chemotherapy drug which causes deleterious effects on testicular tissue and increases free radicals in the body. The aim of this study is to investigate the protective effects of ethyl pyruvate (EP) on testicular improvement in CP treated animals. MaterialsAndMethods In this experimental study, 15 male mice (6-8 weeks) were divided into 3 groups. The control...

Background Cyclophosphamide (CP) is a chemotherapeuticdrug which causes deleterious effects on tissue of testicle and increases free radicals in the body. The aim of this study is to investigate protective effects of ethyl pyruvate (EP) on improvement of testicle inCP treated animals. MaterialsAndMethods In this study, 15 male mice(6-8 weeks) were divided into 3 groups. Control group receivedno...

Procedures have been developed to label human erythropoietin (Ep) with biotin to detect and isolate the Ep-receptor. The labeling method used the abundant carbohydrate groups on Ep and resulted in biologically active biotin-Ep (b-Ep) containing 8 to 10 biotins per Ep molecule. Specific binding of b-Ep to cells from spleens of mice made anemic by phenylhydrazine injections was demonstrated using...

Inclusive production of D(2010) mesons in deep inelastic scattering has been measured using ep and ep data obtained with the ZEUS detector at HERA using integrated luminosities of 16.7 and 65.2pb, respectively. The decay channel D → Dπ with D → Kπ and corresponding antiparticle decays were used to identify D mesons. The D cross sections in ep and ep interactions agree with NLO QCD predictions, ...

We have developed a new approach (MDLEP) to learning Bayesian network structures based on the Minimum Description Length (MDL) principle and Evolutionary Programming (EP). It integrates a MDL metric founded on information theory and several new genetic operators including structure-guided operators, a knowledge-guided operator, a freeze operator, and a defrost operator for the discovery process...

By retrieving records from Taiwan's National Health Insurance (NHI) system's database, the current study aimed to investigate the impacts of hysterosalpingography (HSG) to patients after ectopic pregnancy (EP) operations in Taiwan.In this retrospective cohort study, insurance claims data from 1997 to 2013, derived from a cohort of 1 million people randomly sampled to represent all NHI beneficia...

ectopic pregnancy (ep) is the most important cause of maternal death in the first trimester accounting for 9 - 13% of all pregnancy-related deaths (1). despite the use of transvaginal sonography and high sensitive quantitative beta-hcg assays for diagnosis, nearly 40-50% of all eps may be initially misdiagnosed (2). therefore, several biomarkers have been investigated for early diagnosis of ep....