نتایج جستجو برای: enhancer agents
تعداد نتایج: 380093 فیلتر نتایج به سال:
Enhancers play a crucial role in gene regulation but the participation of enhancer transcripts (i.e. enhancer RNA, eRNAs) in regulatory systems remains unclear. We provide a computational analysis on eRNAs using genome-wide data across 12 mouse tissues. The expression of genes targeted by transcribing enhancer is positively correlated with eRNA expression and significantly higher than expressio...
The polycythemic strain of the spleen focus-forming virus (SFFVp) contains the most potent murine retroviral enhancer configuration known so far for gene expression in myeloerythroid hematopoietic cells. In the present study, we mapped two crucial elements responsible for the high activity of the SFFVp enhancer to an altered upstream control region (UCR) containing a GC-rich motif (5'-GGGCGGG-3...
We have analyzed the structures, relative organization, and activities of binding sites for nuclear factors in the duck hepatitis B virus (duck HBV) enhancer. DNase I footprinting analysis and mobility shift assays demonstrate that this enhancer of 192 bp contains at least three binding sites for transcription factors: one for hepatocyte-adipocyte C/EBP, a second for the liver-specific transact...
In this study we examine the molecular basis for the synergistic regulation of the minimal TCRa enhancer by multiple proteins. We find that reconstitution of TCRc~ enhancer function in nonlymphoid cells requires expression of the lymphoid-specific proteins LEF-1, Ets-1 and PEBP2a (CBFc~I, and a specific arrangement of their binding sites in the enhancer. We show that Ets-1 cooperates with PEBP2...
Abstract: Background: The objective of this current study was to fabricate and characterize the sustained release double layered transdermal patches Diclofenac Diethylamine using hydrophobic acrylic polymer Eudragit RL 100 hydrophilic Polyvinyl pyrrolidone K-30 in combination as first layer matrix type patch pressure sensitive adhesive Duro Tak 387- 2510 second drug-in-adhesive provide anti-inf...
Topical drug dosage forms such as ointments and creams can be easily removed through wetting, movement and contact. The new bioadhesive formulations with enhanced local anesthetic effects are needed for topical administration. The adhesive capacity of hydroxypropyl methylcellulose (HPMC) was determined by measuring the maximum detachment force and the adhesion work with an auto peeling test...
BACKGROUND Mycobacterium avium subspecies paratuberculosis (MAP) causes a chronic wasting diarrheal disease in ruminants called Johne's disease, that is evocative of human inflammatory bowel disease (IBD). Agents used to treat IBD, called "anti-inflammatories", immuno-modulators" and "immuno-suppressants" inhibit MAP growth in culture. We concluded that, unknowingly, the medical profession has ...
Fig. 18 Shown are the regulatory elements characterized so far, which control the transcription of the tyrosine aminotransferase (TAT) gene. The TAT gene may be induced either by glycocorticoids or by cyclic adenosine monophosphate (cAMP), which activates the protein kinase A. All distances are given in kilobases (kb) and refer to the starting point of the TAT gene transcription (arrow). mediat...
We have recently shown that non-viral gene therapy can stabilise the decline of lung function in patients with cystic fibrosis (CF). However, the effect was modest, and more potent gene transfer agents are still required. Fuson protein (F)/Hemagglutinin/Neuraminidase protein (HN)-pseudotyped lentiviral vectors are more efficient for lung gene transfer than non-viral vectors in preclinical model...
Rationale: ANP (atrial natriuretic peptide) and BNP (B-type peptide), encoded by the clustered genes Nppa Nppb , are important prognostic, diagnostic, therapeutic proteins in cardiac disease. The spatiotemporal expression pattern stress-induction of tightly regulated, possibly involving their coregulation an evolutionary conserved enhancer cluster. Objective: To explore physiological functions ...
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