objective: immunotoxins (its) have been developed for the treatment of cancer, and comprise of antibodies linked to toxins. also vascular endothelial growth factor (vegf) plays a key role in tumor angiogenesis, and the blockade of vegf receptor-2 (vegfr2) inhibits angiogenesis and tumor growth. the aim of this study was to produce anti-vegfr2/rpe (pseudomonas exotoxin) 38 it to test its cytotox...

Abstract Current treatments have shown limited success in reversing DM induced vascular endothelial barrier dysfunction. Vascular endothelium forms the inner most lining of blood vessels, regulates variety biological processes such as angiogenesis, wound healing and host defense mechanisms. During inflammatory conditions, diabetes mellitus myocardial infarction cell-cell junctions start to disr...

OBJECTIVE: The goal of this study was to ferment yoghurt from milk using lactic acid bacteria found in pinecones and examine the cell viability lipid peroxidation levels fermented on Vascular Endothelial Cell Line ECV304.
 METHODS: ECV304 cultured vitro. To determine viability, various concentration yogurt extract with pinecone were given cells MTT Assay. At same doses as Assay, Lipid Pero...

Endothelial cell loss is a key indicator of the quality anterior segment surgery like cataract surgery. The amount and integrity corneal endothelial cells are two most essential factors determining transparency. Aim this study was to compare between superior scleral tunnel incision temporal clear for phacoemulsification. Prospective observational study. This prospective included 50 patients wit...

purpose: to compare the clinical and paraclinical outcomes following deep anterior lamellar keratoplasty (dalk) using frozen versus fresh corneas in patients with keratoconus. methods: in this prospective, comparative interventional study, 16 frozen and 19 fresh corneas were used during dalk in keratoconus patients. big bubble technique was used in all patients. the two groups were compared at ...

purpose: optisol-gs is still the most popular cold storage medium used in the united states for short term preservation of donated corneas. cebi medium is a new cold storage medium made by the central eye bank of iran for donor cornea storage. this study was conducted to compare the quantitative and qualitative indices of the donated corneas maintained in optisol-gs versus in the cebi medium. m...

Vascular endothelial growth factor receptor-2 (VEGFR-2); a cell surface receptor for vascular endothelial growth factors, is a key pharmacological target involved in the cell proliferation/angiogenesis. It has been revealed that VEGFR-2 induces proliferation through activation of the extracellular signal-regulated kinases pathway. In this regard, targeting the VEGFR-2 has been considered as an ...

Vascular endothelial growth factor (VEGF) is a multifunctional cytokine with distinct functions in angiogenesis, lymphangiogenesis, vascular permeability, and hematopoiesis. VEGF is a highly conserved, disulfide-bonded dimeric glycoprotein of 34 to 45 kDa produced by several cell types including fibroblasts, neutrophils, endothelial cells, and peripheral blood mononuclear cells, particularly T ...