In July and August 2014, the European Medicines Agency (EMA) organised two public consultations concerning European pharmacovigilance. These two consultations reveal a number of EMA proposals that are counterproductive to the objective of improving transparency over pharmacovigilance data. The EMA's proposals offer pharmaceutical companies an opportunity to participate in public hearings held b...

The paper investigates the relation between the parameters of an autoregressive moving average (ARMA) model and its equivalent moving average (EMA) model. On the basis of this relation, a new method is proposed for determining the ARMA model parameters from the coefficients of a finite-order EMA model. This method is a three-step approach: in the first step, a simple recursion relating the EMA ...

2,2-Bis[4-(2-methacryloxyethoxy)phenyl] propane (bisEMA; CAS 24448-20-2) is an epoxy methacrylate that was developed as a substitute for another epoxy methacrylate, 2,2-bis[4-(2-hydroxy-3-methacryloxypropoxy) phenyl]propane (bis-GMA; CAS 1565-94-2), used in dental composite resins. In the 2012 Finnish Product Register of Chemicals, bis-EMA appears in some anaerobic glues and in one gelcoat. Som...

With the implementation of Article 57(2) in 2012 the European Medicines Agency (EMA) embarked on a digitalization journey that foreseeably would ensure greater product oversight and interoperability across the community. This initiative has subsequently led to additional focus from the agency with respect to the utilization and harmonization of data as part of the regulatory process. Driven by ...

The aim of this study was to identify a suitable method for detecting lymph node metastasis of gastric cancer (GCA) by hematoxylin and eosin (HE) and immunohistochemical (IHC) staining. We investigated lymph node metastasis using pan-cytokeratin (CK) and epithelial membrane antigen (EMA) IHC staining in a total of 1,422 lymph nodes from 100 patients who underwent radical gastrectomy between 200...

As the aviation industry evolves toward next-generation fly-by-wire vehicles, hydraulic actuators are being replaced with their electro-mechanical actuator (EMA) counterparts. By eliminating fluid leakage problems while reducing weight and enhancing vehicle control, the feasibility of EMAs in avionic applications has been established. However, due to the inherent nature of electronic components...