Objective: To determine the hysteroscopic appearance of endometrial hyperplasia in women with subsequently confirmed diagnosis of endometrial hyperplasia. Methodology: This study was done in Aria Hospital in Ahwaz,Iran fromJanuary 21, 2003 to May 24th 2005. Fifty women underwent hysteroscopy with eye direct biopsy of the endometrium. Cause of hysteroscopy was Abnormal Uterine Bleeding (AUB) in ...

Endometriosis, defined as growth of the endometrial cells outside the uterus, is an inflammatory disorder that is associated with chronic pelvic pain and infertility in women of childbearing age. Although the estrogen-dependence of endometriosis is well known, the role of progesterone in development of this disease remains poorly understood. In this study, we developed a disease model in which ...

The complexity of genetic alterations in invasive cancers and the heterogeneity of tumor cell populations hamper attempts to translate molecular understanding at the genetic level into accurate diagnostic and therapeutic approaches. Delineation of molecular changes in the initial stages of tumor development is, therefore, highly desirable because such information can be translated into more eff...

Women who have abnormal Papanicolaou test results may undergo colposcopy to determine the biopsy site for histologic evaluation. Traditional grading systems do not accurately assess lesion severity because colposcopic impression alone is unreliable for diagnosis. The likelihood of finding cervical intraepithelial neoplasia grade 2 or higher increases when two or more cervical biopsies are perfo...

Background: Postmenopausal bleeding (PMB) is one of the most common reasons for referral to tertiary care centres with a strong suspicion malignancy. Endometrial cancer cause gynaecological malignancy in West, but India incidence rates are low. Eighty ninety percent (80-90%) women have benign conditions India. The aim and objectives my study evaluate causes PMB sociodemographic characteristics ...

BACKGROUND Endometriosis is a common disease characterized by the presence of a functional endometrium outside the uterine cavity, causing pelvic pain, dysmenorrheal, and infertility. This disease has been associated to development of different types of malignancies; therefore new blood vessels are essential for the survival of the endometrial implant. Our previous observations on humans showed...

Unopposed estrogen stimulation and insulin resistance are known to play important roles in endometrial cancer (EC), but the interaction between these two factors and how they contribute to endometrial lesions are not completely elucidated. To investigate the endometrial transcriptome profile and the associated molecular pathway alterations, we established an ovariectomized C57BL/6 mouse model t...