OBJECTIVES To explore the roles of Bcl-xl and Bcl-xs in the development and progression of endometrial carcinoma, and to analyze the correlation between Bcl-xl and Bcl-xs. METHODS RT-PCR and Western-blot assay were applied to detect the expressions of Bcl-xl and Bcl-xs in endometrial tissues of various histomorphologic types. RESULTS The Bcl-xl expression levels of simple and atypical hyper...

OBJECTIVE This study was undertaken to evaluate whether it was possible to abstain from performing an endometrial biopsy when endometrial thickness according to transvaginal ultrasonography was /=50 years who were re...

background dysfunctional uterine bleeding (dub) is the most common gynecologic disorder in women of reproductive age. medical treatments are often ineffective. endometrial ablation is an alternative to hysterectomy for these women. objective to evaluate the response to treatment rate of the cavaterm tm plus technique for management of menorrhagia secondary to dysfunctional uterine bleeding (dub...

background and objectives: endometrial hyperplasia (eh) is an abnormal overgrowth of endometrium that may lead to endometrial cancer, especially when accompanied by atypia. the treatment of eh is challenging, and previous studies report conflicting results. metformin (dimethyl biguanide) is an anti-diabetic and insulin sensitizer agent, which is supposed to have antiproliferative and anticancer...

BACKGROUND The incidence and death rates of endometrial cancer are alarmingly increasing. The diagnosis and treatment of endometrial cancer is crucial to decreasing mortality. Cystic fibrosis transmembrane conductance regulator (CFTR) belongs to the adenosine triphosphate (ATP)-binding cassette transporter family and plays an essential role in anion regulation and tissue homeostasis of various ...

The molecular characterization of endometrial endometrioid adenocarcinomas has provided major advances in its prognostic stratification. However, risk assessment microsatellite instability (MSI) and copy-number (CN)-low cases remains a challenge. Thus, we aimed to identify tissue-based morphologic biomarkers that might help the stratification these cases. Histomorphologic parameters (WHO gradin...

the immune responses that develop following epstien-barr virus (ebv) infection are complex and involve both humoral and to a greater extent cell-mediated immune mechanisms. to evaluate the immune response, flow cytometric analysis of the peripheral blood of six patients during the acute phase of ebv infection was performed. this analysis revealed a significant increase in the percentages and th...

The endometrium is a hormonally regulated organ that is non-adhesive to embryos throughout most of the menstrual cycle in humans. Endometrial receptivity refers to a hormone-limited period in which the endometrial tissue acquires a functional and transient ovarian steroid-dependent status allowing blastocyst adhesion. Functional genomic studies of human endometrium in natural cycles have demons...