TAKAHASHI,K.Adrenomedullin from a Pheochromocytoma to the Eye:Implications of the Adrenomedullin Research for Endocrinology in the 21st Century. Tohoku J.Exp.Med.,2001,193(2),79-114 In the last several decades,the concept of“endocrinology”has been greatly changed.One major change was due to the discovery of peptide hormones secreted by the organs that were not “classical”endocrine organs.For ex...

Endocrine disruptors are known to cause harmful effects to human through various exposure routes. These chemicals mainly appear to interfere with the endocrine or hormone systems. As importantly, numerous studies have demonstrated that the accumulation of endocrine disruptors can induce fatal disorders including obesity and cancer. Using diverse biological tools, the potential molecular mechani...

The endocrine system controls the flow of information between cells and tissues, governed by complex regulatory mechanisms (1). Hormones exert widespread influences on various metabolic processes which ensure regulatory, morphogenic and integrative function (2). Signs and symptoms of endocrine disorders span the entire clinical spectrum. Manifestations of endocrine diseases are frequently due t...

Autoimmune polyendocrine syndromes are a heterogeneousgroup of rare diseases characterized by autoimmune activityagainst more than one endocrine organ, although non-endocrineorgans can also be affected. We report the association of APS Iwith erythema annulare centrifugum in an 18-years-old male whopresented with multiple figurate erythema spreading on his trunkand extremities along with a histo...

Endocrine disrupting chemicals (EDC) are compounds that alter the normal functioning of the endocrine system of both wildlife and humans. A huge number of chemicals have been identified as endocrine disruptors, among them several pesticides. Pesticides are used to kill unwanted organisms in crops, public areas, homes and gardens, and parasites in medicine. Human are exposed to pesticides due to...

Currently, non-infectious diseases, among which various disorders of the endocrine system play a decisive role, occupy one first positions in structure morbidity and mortality. Endocrine pathology worsens course other diseases is significant adverse factor increasing mortality, including cardiovascular accidents. Thyroid ranks second an increase incidence prevalence thyroid older age groups has...

Endocrine disrupting chemicals (EDCs) have been shown to interfere with physiological systems, i.e., adversely affecting hormone balance (endocrine system) , or disrupting normal function, in the female and male reproductive organs. Although endocrine disruption is a global concern for human health, its impact and significance and the screening strategy for detecting these synthetic or man-made...