نتایج جستجو برای: endocannabinoid

تعداد نتایج: 3595  

2017
Daniel J Liput James R Pauly Audra L Stinchcomb Kimberly Nixon

Excessive alcohol consumption leads to neurodegeneration, which contributes to cognitive decline that is associated with alcohol use disorders (AUDs). The endocannabinoid system has been implicated in the development of AUDs, but little is known about how the neurotoxic effects of alcohol impact the endocannabinoid system. Therefore, the current study investigated the effects of neurotoxic, bin...

Journal: :The Journal of biological chemistry 2012
Mária Szekeres György L Nádasy Gábor Turu Eszter Soltész-Katona Zsuzsanna E Tóth András Balla Kevin J Catt László Hunyady

In the vascular system angiotensin II (Ang II) causes vasoconstriction via the activation of type 1 angiotensin receptors. Earlier reports have shown that in cellular expression systems diacylglycerol produced during type 1 angiotensin receptor signaling can be converted to 2-arachidonoylglycerol, an important endocannabinoid. Because activation of CB(1) cannabinoid receptors (CB(1)R) induces v...

Journal: :Archives of oral biology 2010
Javier Fernandez-Solari Juan Pablo Prestifilippo Cesar Angel Ossola Valeria Rettori Juan Carlos Elverdin

OBJECTIVE The aim of the present paper was to assess whether lipopolysaccharide (LPS)-induced inhibition of salivary secretion involves the activation of the endocannabinoid system and the participation of tumor necrosis factor (TNF)alpha in the submandibular gland. DESIGN Pharmacological approaches were performed by using CB1 and/or CB2 cannabinoid receptor antagonists, AM251 and AM630, resp...

2013
Matthijs G. Bossong J. Martijn Jansma Hendrika H. van Hell Gerry Jager René S. Kahn Nick F. Ramsey

Evidence is increasing for involvement of the endocannabinoid system in cognitive functions including attention and executive function, as well as in psychiatric disorders characterized by cognitive deficits, such as schizophrenia. Executive function appears to be associated with both modulation of active networks and inhibition of activity in the default mode network. In the present study, we ...

2011
Andrea Cippitelli Giuseppe Astarita Andrea Duranti Giovanni Caprioli Massimo Ubaldi Serena Stopponi Marsida Kallupi Gianni Sagratini Fernando Rodrìguez de Fonseca Daniele Piomelli Roberto Ciccocioppo

Evidence shows that the endocannabinoid system modulates the addictive properties of nicotine. In the present study, we hypothesized that spontaneous withdrawal resulting from removal of chronically implanted transdermal nicotine patches is regulated by the endocannabinoid system. A 7-day nicotine dependence procedure (5.2 mg/rat/day) elicited occurrence of reliable nicotine abstinence symptoms...

Journal: :Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 2011
V Di Marzo F Piscitelli

Stemming from the centuries-old and well known effects of Cannabis on intestinal motility and secretion, research on the role of the endocannabinoid system in gut function and dysfunction has received ever increasing attention since the discovery of the cannabinoid receptors and their endogenous ligands, the endocannabinoids. In this article, some of the most recent developments in this field a...

2015
Panagiotis Zogopoulos Georgios Vretakos Dimitrios Rologis

Over the last years, considerable progress has been made in understanding the role of the endocannabinoid system in the modulation of several progressive neurodegenerative diseases. The endocannabinoid system, comprised of cannabinoid receptors (type-1 and type-2), their endogenous ligands [referred to as endocannabinoids, of which anandamide (AEA) and 2-arachidonoylglycerol (2-AG) are most stu...

Journal: :Brain : a journal of neurology 2007
Diego Centonze Monica Bari Silvia Rossi Chiara Prosperetti Roberto Furlan Filomena Fezza Valentina De Chiara Luca Battistini Giorgio Bernardi Sergio Bernardini Gianvito Martino Mauro Maccarrone

The ability of cannabinoids to modulate both inflammatory and degenerative neuronal damage prompted investigations on the potential benefits of such compounds in multiple sclerosis (MS) and in animal models of this disorder. Here we measured endocannabinoid levels, metabolism and binding, and physiological activities in 26 patients with MS (17 females, aged 19-43 years), 25 healthy controls and...

2017
Agnieszka Gęgotek Paula Rybałtowska-Kawałko Elżbieta Skrzydlewska

Background. Rutin is a natural nutraceutical that is a promising compound for the prevention of UV-induced metabolic changes in skin cells. The aim of this study was to examine the effects of rutin on redox and endocannabinoid systems, as well as proinflammatory and proapoptotic processes, in UV-irradiated fibroblasts. Methods. Fibroblasts exposed to UVA and UVB radiation were treated with ruti...

2008
Anton Sheinin Giuseppe Talani Margaret I. Davis David M. Lovinger

Endocannabinoids released from the postsynaptic neuronal membrane can activate presynaptic CB1 receptors and inhibit neurotransmitter release. In hippocampal slices, depolarization of the CA1 pyramidal neurons elicits an endocannabinoid-mediated inhibition of GABA release known as depolarization-induced suppression of inhibition (DSI). Utilizing the highly reduced neuron/synaptic bouton prepara...

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