Acute disseminated encephalomyelitis (ADEM) is an inflammatory demyelinating disease of the central nervous system that is usually considered a monophasic disease. ADEM forms one of several categories of primary inflammatory demyelinating disorders of the central nervous system including multiple sclerosis, optic neuropathy, acute transverse myelitis, and neuromyelitis optica (Devic's disease)....

Introduction. Myelin oligodendrocyte glycoprotein antibody associated disorders (MOGAD) are immunemediated inflammatory conditions of the central nervous system (CNS) with a wide clinical phenotypic variability. In order to further understand possible phenotype MOGAD here we report pediatric case acute disseminated encephalomyelitis (ADEM) MOG antibodies. Case outline. A previously healthy four...

Regulatory T cells are crucial in controlling various functions of effector T cells during experimental autoimmune encephalomyelitis. While regulatory T cells are reported to exert their immunomodulatory effects in the peripheral immune organs, their role within the central nervous system (CNS) during experimental autoimmune encephalomyelitis is unclear. Here, by combining a selectively timed r...

The ubiquitin ligase Peli1 has previously been suggested as a potential treatment target in multiple sclerosis. In the multiple sclerosis disease model, experimental autoimmune encephalomyelitis, Peli1 knock-out led to less activated microglia and less inflammation in the central nervous system. Despite being important in microglia, Peli1 expression has also been detected in glial and neuronal ...

multiple sclerosis (ms) is an autoimmune disease in which auto-reactive t cells react with self-antigens expressed in the central nervous system (cns). the main cause of ms is unknown. nonetheless, the most probable theory is based on molecular mimicry, which suggests that some infections can activate t cells against brain auto-antigens like myelin proteolipid protein (plp) and initiate the dis...

how to cite this article: inaloo s, haghbin s, moradi m, dashti h, safari n. acquired cns demyelinating syndrome in children referred to shiraz pediatric neurology ward. iran j child neurol. 2014 spring; 8(2):18-23. objective incidence of cns acquired demyelinating syndrome (ads), especially multiple sclerosis (ms) in children, appears to be on the rise worldwide. the objective of this study wa...