The compound MG-1(R,S), (1-[2-hydroxy-3(4-phenyl-1-piperazinyl)propyl]-pyrrolidin-2-one, and its enantiomers were tested for electrocardiographic, antiarrhythmic and hypotensive activities. The racemic mixture (MG-1(R,S)) and its S-enantiomer significantly decreased systolic and diastolic blood pressure and possessed antiarrhythmic activity. The S-enantiomer displayed the greatest effect. The R...

Male Locusta hemolymph contains JH-esterase(s) and a JH-carrier protein with high affinity and low capacity that both interact enantioselectively with juvenile hormones. Exposure of racemic JH-I and JH-III results in preferential hydrolysis of the naturally configurated enantiomer of JH-I but the unnaturally configurated enantiomer of JH-III. The JH-carrier protein has a remark­ able specificit...

Efficient near-infrared circularly polarised luminescence (CPL) between 1400 and 1600 nm of four enantiomer pairs homo- heteroleptic complexes have been successfully measured.

We investigated the stereoselective inhibition of growth and ergosterol biosynthesis by SCH39304 in the pathogenic fungus Cryptococcus neoformans obtained from four AIDS patients who failed fluconazole therapy and compared the results to those obtained with a wild-type strain. For all strains, the MICs of the RR isomer were approximately half those of the racemate, with the SS enantiomer showin...

The relationship between chiral inversion and stereoselective amino acid conjugation of a new nonsteroidal anti-inflammatory agent, R, S-2-[4-(3-methyl-2-thienyl)phenyl]propionic acid (R,S-MTPPA) was investigated in rats and dogs. Only the S-enantiomer was found in plasma after oral administration of S-MTPPA to both species. In contrast, the R- and S-enantiomers were both detected after the dos...

Title: Enantiomer-specific isotope analysis (ESIA) of D-and L-alanine: nitrogen isotopic hetero-and homogeneity by microbial process and chemical process. Abstract Nitrogen isotopic hetero-and homogeneity of D-α-alanine and L-α-alanine were investigated in microbial processes in the domain Bacteria and in chemical processes in symmetric organic synthesis. D-alanine is an enantiomer that is phys...

A potentiometric sensor for enantiomers has been prepared with no chiral additives, only cobaltabisdicarbollide and the protonated enantiomer.

A glandular secretion of the civet cat, (2S,6S)-(6-methyltetrahydropyran-2-yl)acetic acid 1 and its enantiomer, were synthesized from the yeast-reduction product and recovered substrate from yeast reduction.

Single crystal X-ray diffraction has been used as one of the common methods for the unambiguous determination of the absolute stereostructure of chiral molecules. However, this method is limited to molecules containing heavy atoms or to molecules with the possibility of functionalization with heavy elements or chiral internal references. Herein, we report the determination of the absolute stere...