Self-emulsifying drug delivery systems (SNEDDS) are highly in quest due to their innumerable benefits like better portability, improved stability and higher drug loading, coupled with ease and economy of their production. SNEDDS are used to improve the solubility of high lipophilic drugs. SNEDDS are improving the oral bioavailability of limited water-soluble drug compounds. These SNEDDS are iso...

European eel proteins hydrolysates (EPHs) were produced from A. anguilla muscle protein and isolate using Purafect®, goby crude proteases B. invictae proteases. EPHs had high contents displayed diverse molecular mass distributions. Muscle (MPHs) (PIHs) obtained both by Purafect® the highest antibacterial activity. PIHs emulsifying stability. MPHs higher chelating effects. ability to prevent ble...

High-frequency spectroscopy has been applied to monitoring the stability of oil-in-water emulsions. It was found that stable emulsions showed absorption peaks at around 550 MHz; further, they shifted from lower to higher frequencies with time. The rate of increase of the frequencies was dependent on the amount of emulsifier added. These results show that the stability of emulsions can be monito...

Self-emulsifying drug delivery systems (SEDDSs) are lipid-based anhydrous formulations composed of an isotropic mixture of oil, surfactant, and cosurfactants usually presented in gelatin capsules. Ravuconazole (Biopharmaceutics Classification System [BCS] Class II) is a poorly water-soluble drug, and a SEDDS type IIIA was designed to deliver it in a predissolved state, improving dissolution in ...

A previously reported bacterial bioemulsifier, here termed microbactan, was further analyzed to characterize its lipid component, molecular weight, ionic character and toxicity, along with its bioemulsifying potential for hydrophobic substrates at a range of temperatures, salinities and pH values. Analyses showed that microbactan is a high molecular weight (700 kDa), non-ionic molecule. Gas chr...

Enzymatic hydrolysis of proteins can enhance their emulsifying properties and antioxidant activities. However, the problem related to was generation bitter taste. Recently, high hydrostatic pressure (HHP) treatment has attracted much interest been used in several studies on protein modification. Hence, study aimed investigate effects enzymatic by Corolase PP under different treatments (0.1, 100...

BACKGROUND Lagerstroemia speciosa (SEL) leaves are a popular folk medicine for diabetes treatment due to presence of corosolic acid. It has low water solubility resulting poor absorption after oral administration. Self micro-emulsified drug delivery system is the way by which we can improve the oral absorption of drug. OBJECTIVE The objective of this study was to develop the self micro-emulsi...