Abstract Endoscopic third ventriculostomy (ETV) has been accepted for obstructive hydrocephalus (OH). We herein present a case of OH and optic nerve sheath edema (ONSE). Although ETV was successful, ONSE worsened. Discussion is focused on the relationship among intracranial hypertension (IH), ETV, ONSE. The patient 19-year-old woman with complaints headache emesis. Papilledema prominent. Radiol...

BACKGROUND To reduce side-effects of corticosteroid-containing antiemetic regimens, tailoring antiemetic schedules to specific requirements of different patients could be of benefit. We evaluated the possibility to reduce the total dose of corticosteroids when palonosetron, a long-acting second-generation 5-hydroxytryptamine-3 (5-HT(3)) receptor antagonist, is used. MATERIALS AND METHODS Doub...

OBJECTIVE To determine the contribution of dexamethasone to the efficacy of the 5-hydroxytryptamine antagonist ondansetron in control of cisplatin induced nausea and vomiting. DESIGN Randomised double blind crossover study. SETTING Two cancer centres in teaching hospitals, one in the United Kingdom and the other in Germany. SUBJECTS 100 patients (53 men and 47 women) new to cisplatin chem...

OBJECTIVES To determine the thyroid profile and the prevalence of gestational thyrotoxicosis among women with emesis during early pregnancy. DESIGN A descriptive cross-sectional study. SETTING Kenyatta National Hospital acute gynaecology ward and the ante-natal clinic. SUBJECTS Seventy two women presenting with emesis up to 16 weeks gestation. MAIN OUTCOME MEASURES The levels of FT3, FT...

This study aimed to analyse UK pharmacovigilance data to quantify adverse events (AEs) associated with the non-steroidal anti-inflammatory drug (NSAID) molecules found in veterinary medicines authorised for use in dogs and cats. It was hypothesised that the frequency of AEs would be lower when associated with cyclo-oxygenase-2 selective (coxib), compared to non-selective (non-coxib) NSAIDs. The...

BACKGROUND We present a clinical trial to assess the hypothesis that chemotherapy related emesis is reduced when drugs delivered while the patient is sleeping. METHODS Adults without previous sleep disturbances of vomit inducing conditions who were going to receive their first courses of 100 mg/m2 cisplatin were included. We reduced antiemetic prophylaxis consisting of ondansetron and dexamet...

This paper reports that vasopressin is emetogenic in the house musk shrew Suncus murinus. Either intravenous or intracerebroventricular administration of vasopressin caused vomiting within a few minutes. The ED50 of intravenous vasopressin was as high as 4.67 microg/kg, whereas intracerebroventricularly injected vasopressin was effective at a low dose of 20 ng/brain. The emetogenic target of va...

OBJECTIVE To determine the quantitative impact of intravenous dexamethasone on recovery after tonsillectomy using established principles for meta-analysis. STUDY DESIGN/SETTING Double-blind randomized-control trials in which subjects were treated identically except for the presence or absence of perioperative intravenous dexamethasone. Six articles met inclusion criteria. Two investigators ex...