In recently, many studies tried that fine medicinal plant that may be useful in treatment of psychological diseases. Coriandrum sativum (CS) overgrows in the different parts of Iran. In this study we investigated the effects of hydro-alcoholic extract of Coriandrum sativum on anxiety reaction in Mice. In this study, fourty male mice (25-30 gr) in elevated plus maze model were used. Different do...

There is growing interest in flavonoids for their wide array of biological actions. In neurodegenerative disorders these naturally occurring polyphenolic compounds, are known to inhibit proinflammatory mediators such as in TNF–? and IL-6 in lipopolysaccharide (LPS) stimulated neuronal degeneration, which are associated with Alzheimer’s and Parkinson’s disease. Recent studies on flavonoids have ...

Introduction: Lack of high-quality sleep causes serious side effects like anxiety and changes in plasma concentration of oxalate. The current study aimed to investigate the impact of local extremely low frequency magnetic fields (ELF-MFs) on inducing sleep (sleepiness) and anxiety in male rats. Methods: In this experimental study, 40 male rats were allocated in four groups (n=10). The ELF-MFs ...

The study investigated the effects of ‘low doses’ of monosodium glutamate (MSG) on hippocampal-related (spontaneous working-memory, memory-recall and anxiety) behaviours, and hippocampal glutamate/glutamine levels. A two-trial Y-maze test and 8-arm radial-arm maze spontaneous working-memory test were used to assess the effects of acute and repeated administration of MSG, on novel-arm choice on ...

This review focuses on factors influencing behaviour in the elevated plus-maze, the holeboard and the social transmission of food preference. The elevated plus-maze provides independent measures of anxiety (percentage of time spent on open arms) and activity (number of closed arm entries) and can be used in both males and females. Important sex differences emerge in factor loadings, and, wherea...

The role of lateral septal vasopressin (VP) in the modulation of spatial memory, social memory, and anxiety-related behavior was studied in adult, male Wistar rats. Animals were equipped with osmotic minipumps delivering the VP-antagonist d(CH2)5-D-Tyr(Et)VAVP (1 ng/0.5 microl per h) bilaterally into the lateral septum (LS). Subsequently, all rats were subjected to four behavioral tests. First,...

The present study addressed the role of environmental light intensity on the exploratory behavior of rats in the elevated plus-maze, with the specific goal of determining the light intensity threshold for triggering the aversion to the open arms. Male Wistar-derived rats were tested in the elevated plus-maze under different illumination levels: 0, 1, 3, 10, 30, 100 and 300 lx. Exploratory behav...