Characean algae have been a model plant for electrophysiology many decades, due to the large size of internodal cells and their robust recovery from invasive manipulation. The information gained them has provided template understanding groups. relative ability take up or export ions, including nutrients toxins, can be part explanation as why certain macrophytes occur preferably in nutrient-rich...

The diagnosis and treatment of clinical electrophysiology has a long and fascinating history. From the earliest time, no clinical symptom impressed the patient (and the physician) more than an irregular heart beat. Although ancient Chinese pulse theory laid the foundation for the study of arrhythmias and clinical electrophysiology in the 5th century BC, the most significant breakthrough in the ...

CARDIAC ELECTROPHYSIOLOGY CLINICS www.cardiacEP.theclinics.com Consulting Editors RANJAN K. THAKUR ANDREA NATALE June 2022 • Volume 14 Number 2

This open access text aims at giving you the simplest possible introduction to differential equations that are used in models of electrophysiology.

The use of mathematical models to study cardiac electrophysiology has a long history, and numerous cellular scale models are now available, covering a range of species and cell types. Their use to study emergent properties in tissue is also widespread, typically using the monodomain or bidomain equations coupled to one or more cell models. Despite the relative maturity of this field, little has...

Simulation of cardiac electrical activity using the bi-domain equations can be a massively computationally demanding problem. This study provides a comprehensive guide to numerical bi-domain modelling. Each component of bi-domain simulations--discretization, ODE-solution, linear system solution, and parallelization--is discussed, and previously-used methods are reviewed, new methods are propose...

Synthetic opioid agents have been used in modern medicine for over a century and for opioid addiction treatment for over a half-century. Liberal use of opioids in the United States has been attended by an extraordinary increase in opioid-related mortality, with over 16,000 deaths in 2012. As there have been advances in opioid agents for pain and addiction, so have there been advances in our und...

The combination of computational models and biophysical simulations can help to interpret an array of experimental data and contribute to the understanding, diagnosis and treatment of complex diseases such as cardiac arrhythmias. For this reason, three-dimensional (3D) cardiac computational modelling is currently a rising field of research. The advance of medical imaging technology over the las...

In this study we present a novel computational model for unprecedented simulations of the whole cardiac electrophysiology. According to heterogeneous electrophysiologic properties heart, geometry is decomposed into set coupled conductive media having different topology and electrical conductivities: (i) network slender bundles comprising fast conduction atrial network, AV–node ventricular bundl...

The simulation of cardiac electrophysiology is a mature field in computational physiology. Recent advances in medical imaging, high-performance computing and numerical methods mean that computational models of electrical propagation in human heart tissue are ripe for use in patient-specific simulation for diagnosis, for prognosis and for selection of treatment methods. However, in order to move...