Protein kinases are key regulators of signal transduction pathways that participate in diverse cellular processes. In fungal pathogens, kinases regulate signaling pathways that govern drug resistance, stress adaptation, and pathogenesis. The impact of kinases on the fungal regulatory circuitry has recently garnered considerable attention in the opportunistic fungal pathogen Candida albicans, wh...

T he fungal kingdom encompasses 1.5 million species (1) as diverse as single-celled yeasts, pathogens of animals/plants, and plant root symbionts. Fungi are eukaryotic, closely aligned with metazoans (2, 3). Animals and fungi diverged 1 billion years ago; their last common ancestor was unicellular, motile, and aquatic. Some fungi grow as unicellular yeasts, but most are filamentous multicellula...