Epoxyeicosatrienoic acids (EETs) and the cytochrome P450 epoxygenase CYP2J2 promote tumorogenesis in vivo and in vitro via direct stimulation of tumor cell growth and inhibition of tumor cell apoptosis. Herein, we describe a novel mechanism of inhibition of tumor cell apoptosis by EETs. In Tca-8113 cancer cells, the antileukemia drug arsenic trioxide (ATO) led to the generation of reactive oxyg...

Introduction: Ureilites are a group of carbonbearing ultramafic achondrites. The majority of samples are monomict with major and trace element compositions consistent with a restitic origin after extensive loss of basaltic melts and significant loss of their metallic component during anatexis. Monomict ureilites are thought to represent largely intact samples of the ureilite parent body (UPB) m...

Cytochrome P-450 (CYP450) enzymes of the CYP2 and -4 family in humans metabolize arachidonic acid to generate bioactive epoxyeicosatrienenoic acids (EETs) and hydroxyeicosatetrenoic acids (HETEs). We report significantly higher levels of CYP 2J2 protein expression following the onset of labor (n = 6, P < 0.05), implying increased EET-generating capacity within the uterus. Myometrial relaxation ...

An intriguing observation of photosynthetic light-harvesting systems is the N-fold symmetry of light-harvesting complex 2 (LH2) of purple bacteria. We calculate the optimal rotational configuration of N-fold rings on a hexagonal lattice and establish two related mechanisms for the promotion of maximum excitation energy transfer (EET). (i) For certain fold numbers, there exist optimal basis cell...

Chlorosomes are the largest light harvesting complexes in nature and consist of many bacteriochlorophyll pigments forming self-assembled J-aggregates. In this work, we use two-dimensional electronic spectroscopy (2D-ES) to investigate ultrafast dynamics of excitation energy transfer (EET) in chlorosomes and their temperature dependence. From time evolution of the measured 2D electronic spectra ...

BACKGROUND/AIMS Epoxyeicosatrienoic acids (EETs), a type of lipid mediators produced by cytochrome P450 epoxygenases, exert anti-inflammatory, angiogenic, anti-oxidative and anti-apoptotic effects. However, the role of EETs in cigarette smoke-induced lung injury and the underlying mechanisms are not fully known. The aim of this study was to explore the effects of CYP2J2-EETs on cigarette smoke ...

The Electronic Engineering Technology (EET) Program plays an important role in the University of Southern Mississippi (USM). The EET program strives to create a learning environment that nurtures the development of critical thinking skills, and develops technology expertise. Traditionally, our courses in Engineering Technology, such as Electrical Power, tend to cover a lot of details from a tec...

Reprogramming of gene expression contributes to structural and functional adaptation of muscle tissue in response to altered use. The aim of this study was to investigate mechanisms for observed improvements in leg extension strength, gain in relative thigh muscle mass and loss of body and thigh fat content in response to eccentric and conventional strength training in elderly men (n = 14) and ...

Fang, Xiang, Shanming Hu, Bingkun Xu, Gary D. Snyder, Shawn Harmon, Jianrong Yao, Yi Liu, Bhavani Sangras, J. R. Falck, Neal L. Weintraub, and Arthur A. Spector. 14,15-Dihydroxyeicosatrienoic acid activates peroxisome proliferator-activated receptor. Am J Physiol Heart Circ Physiol 290: H55–H63, 2006. First published August 19, 2005; doi:10.1152/ajpheart.00427.2005.— Epoxyeicosatrienoic acids (...

Non-cognitive features including personality changes are increasingly recognized in the three PPA variants (semantic-svPPA, non fluent-nfvPPA, and logopenic-lvPPA). However, differences in emotion processing among the PPA variants and its association with white matter tracts are unknown. We compared emotion detection across the three PPA variants and healthy controls (HC), and related them to w...