Poverty alleviation linked to agricultural intensification has been achieved in many regions but there is often only limited understanding of the impacts on ecological dynamics. A central need is to observe long term changes in regulating and supporting services as the basis for assessing the likelihood of sustainable agriculture or ecological collapse. We show how the analyses of 55 time-serie...

The innovation process has intensified as a result of the application of new digital technologies. These technologies that simulate, model and integrate, intensify the innovation process through facilitating economy of effort and definiteness of aim. Of all the many analytical lenses used to examine innovation, the most valuable in accounting for this " automation of innovation " is Rothwell's ...

This paper is a commentary on Beltrama and Bochnak (2015), who propose a uniform semantics for different uses of cross-categorial intensifiers -issimo in Italian and šému in Washo as universal quantifiers over contexts. Two concerns of their uniform semantics are raised, (i) unexpected restrictions on intensification, and (ii) non-truth-conditional intensification. It is argued that a uniform s...

The benefits of achieving a long term event free survival of 60-70% by using increasingly intense treatment regimens must be weighed against the increased risk of treatment toxicity. From 1985 to 1990, 1612 children with childhood acute lymphoblastic leukaemia (ALL) in the UK were treated on MRC UKALL X with intensive induction therapy, central nervous system directed therapy (cranial irradiati...

BACKGROUND Residual viraemia is a major obstacle to HIV-1 eradication in subjects receiving HAART. The intensification with raltegravir could impact latent reservoirs and might lead to a reduction of plasma HIV-1 viraemia (viral load [VL]), complementary DNA intermediates and immune activation. METHODS This was a prospective, open-label, randomized study comprising 69 individuals on suppressi...

The Brazilian Amazon is one of the most rapidly developing agricultural frontiers in the world. The authors assess changes in cropland area and the intensification of cropping in the Brazilian agricultural frontier state of Mato Grosso using remote sensing and develop a greenhouse gas emissions budget. The most common type of intensification in this region is a shift from singleto doublecroppin...

BACKGROUND In response to the short-term negative inotropic and chronotropic effects of β-blockers, heart failure (HF) guidelines recommend initiating β-blockers at low dose with gradual uptitration as tolerated to doses used in clinical trials. However, patterns and safety of β-blocker intensification in routine practice are poorly described. METHODS We described β-blocker intensification am...