the highly substituted pyridine derivatives are found to exhibit diverse pharmacological activities. they are also emerged as potential medicinal leads in developing therapeutic agents for the treatment of various diseases. in this work, a series of 2-amino-3,5-dicarbonitrile-6-thio-pyridine derivatives have been synthesized at room temperature via one-pot, multi-component reaction of various a...

“In primitive traffic the economic man is awaking but very gradually to an understanding of the economic advantages to be gained by exploitation of existing opportunities of exchange...Consider how seldom it is the case, that a commodity owned by somebody is of less value in use than another commodity owned by someone else! And for the latter just the opposite relation is the case. But how much...

This article proposes three ideal business models to analyze innovation in knowledge-intensive goods and services. The three models are 1) Firm-based control, 2) Hybrid, and 3) Network-based. Each is defined in relation to the two sides of innovation, e.g. creation of novelty and of economic value. Defining the models this way leads to a discussion of the advantages and disadvantages of each mo...