نتایج جستجو برای: early cleavage
تعداد نتایج: 729833 فیلتر نتایج به سال:
Lysosomal membrane permeabilization (LMP) is emerging as an important regulator of cell apoptosis. Human neutrophils are highly granulated phagocytes, which respond to pathogens by exhibiting increased production of reactive oxygen species (ROS) and lysosomal degranulation. In a previous study, we observed that intracellular, nonphagosomal generation of ROS triggered by adherent bacteria induce...
b-Site amyloid precursor protein cleavage enzyme (BACE)-1and BACE-2 are members of a novel family of membrane-bound aspartyl proteases. While BACE-1 is known to cleaveb-amyloid precursor protein (bAPP) at the b-secretase siteand to be required for the generation of amyloid b-peptide(Ab), the role of its homologue BACE-2 in amyloidogenesis isless clear. We now demonst...
Spiralian development is characterized by the conservation of spindle orientation and cell geometry during early cleavage stages, as well as features of the ultimate fates of identified cells. This complex set of characters is shared by a number of animal lineages including nemerteans, polyclad platyhelminthes, annelids and mollusks. How a similar, highly stereotypical cleavage program can give...
-Chlor i te-mica aggregates in slates from northern Spain have been investigated in very-thin thin sections. Specimens from various parts of a fold show different morphologies that are dependent on the operating deformation mechanism. From the limb to the hinge rigid-body rotation becomes less important and folding and intragranular kinking are more common. This is associated with an increasing...
BACKGROUND Embryo quality may be accurately assessed as early as the pronuclear zygote phase, as shown in recent studies. However, it is not known whether good quality zygotes are destined to become good quality cleavage stage embryos and blastocysts. METHODS In this retrospective study, 86 intracytoplasmic sperm injection-embryo transfer cycles were studied where each available embryo was sc...
In order to estimate the diversity of embryo cleavage relatives to embryo progress (blastocyst formation), time-lapse imaging data of preimplantation human embryo development were used. This retrospective study is focused on the topographic features and time parameters of the cleavages, with particular emphasis on the lengths of cleavage cycles and the genealogy of blastomeres in 2- to 8-cell h...
Huntington's disease (HD) results from polyglutamine expansion in huntingtin (htt), a protein with several consensus caspase cleavage sites. Despite the identification of htt fragments in the brain, it has not been shown conclusively that htt is cleaved by caspases in vivo. Furthermore, no study has addressed when htt cleavage occurs with respect to the onset of neurodegeneration. Using antibod...
The morphogenetic relationship between early patterning and polarity formation is of fundamental interest and remains a controversial issue in preimplantation embryonic development. We use a label-free three-dimensional (3-D) imaging technique of full-field optical coherence tomography (FF-OCT) successfully for the first time to study the dynamics of developmental processes in mouse preimplanta...
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