Endovascular treatment of symptomatic peripheral artery disease has traditionally been performed with percutaneous transluminal angioplasty (PTA), although long-term patency in femoropopliteal arteries remains unsatisfactory. The use of bare metal stents in the femoropopliteal arteries has led to improved safety and patency compared to PTA although neointimal hyperplasia proliferation leading t...

As randomized clinical trial (RCT) programs have increasingly become more global geographically, numerous challenges have resulted. One issue that arises with such global programs is the sometimes differing regulatory advice or requirements on primary or secondary endpoints. The International Conference on Harmonization of Technical Requirements for Registration of Pharmaceuticals for Human Use...

The classical APT model is of the form j j j j EI I r E r ε β + − = − ) ( ) ( , where ) ( j j r E r − is the earning deviation (called basic variance-profit) of the security I j, is a common factor. This paper considers the impact on the securities return caused by the skewness and kurtosis of the stock returns distributions, and poses a re-modified the arbitrage pricing model as follows j j j ...

We have utilized an in vivo-inducible genetic-fate-mapping strategy to permanently label cohorts of Math1-positive cells and their progeny that arise in the rhombic lip of the cerebellar primordium during embryogenesis. At stages prior to E12.5, with the exception of the deep cerebellar nuclei, we find that Math1 cells migrate out of the cerebellar primordium into the rostral hindbrain to popul...

Factor models have been successfully employed in summarizing large datasets with few underlying latent factors and in building time series forecasting models for economic variables. When the objective is to forecast a target variable y with a large set of predictors x, the construction of the summary of the xs should be driven by how informative on y it is. Most existing methods first reduce th...

We have developed a primary dissociated cell culture of the fetal (E17) and post-natal (P0-P10) rat auditory cortex. Pyramidal and non-pyramidal cells had a mean cross-sectional diameter of 12.73 +/- 1.80 microns (mean +/- S.D., n = 25) and 17.58 +/- 1.67 microns (mean +/- S.D., n = 10), respectively, measured at 6 days in culture. These cells were viable for as long as 18-21 days. They express...

5 Geoffrey W. Birrell, Marina Chavchich, Arba L. Ager, Hong-Ming 6 Shieh, Gavin D. Heffernan, Wenyi Zhao, Peter E. Krasucki, Kurt W. 7 Saionz2, Jacek Terpinski2, Guy A. Schiehser2, Laura R. Jacobus2, G. 8 Dennis Shanks1, David P. Jacobus2 and Michael D. Edstein1* 9 10 Department of Drug Evaluation, Australian Army Malaria Institute, Enoggera, 11 Brisbane, Queensland 4051, Australia 12 Jacobus P...

The distribution of the c-myc protein was studied in the developing embryo from the two-somite stage to embryonic day 17 (E17). A triple labelling method was used, with a polyclonal serum recognizing the human and avian c-myc proteins as the first marker followed by Hoechst 33258 for nuclear staining and the monoclonal antibody 13F4 which reveals the avian myogenic lineage. In situ hybridizatio...

1. Esmaeli B, Ahmadi MA, Youssef A, et al. Outcomes in patients with adenoid cystic carcinoma of the lacrimal gland. Ophthal Plast Reconstr Surg 2004;20:22-6. 2. Tse DT, Kossler AL, Feuer WJ, Benedetto PW. Long-term outcomes of neoadjuvant intra-arterial cytoreductive chemotherapy for lacrimal gland adenoid cystic carcinoma. Ophthalmology 2013;120:1313-23. 3. Fellman M, Carter K, Call CB, Esmae...