Type 2 diabetes (T2D) has increased dramatically in the last 20 years afflicting more than 425 million people all over world with 34 located US, emphasizing need for strategic therapies including dietary prescriptions or other lifestyle changes to reduce these numbers. In addition abnormally high plasma glucose levels, concentrations of glycosylated hemoglobin and insulin resistance, T2D is als...

251. Efficacy and safety of LDL-lowering therapy among men and women: Meta-analysis of individual data from174 000 participants in 27 randomised trials. The Lancet

Authors/Task Force Members: Željko Reiner* (ESC Chairperson) (Croatia) Alberico L. Catapano* (EAS Chairperson)* (Italy), Guy De Backer (Belgium), Ian Graham (Ireland), Marja-Riitta Taskinen (Finland), Olov Wiklund (Sweden), Stefan Agewall (Norway), Eduardo Alegria (Spain), M. John Chapman (France), Paul Durrington (UK), Serap Erdine (Turkey), Julian Halcox (UK), Richard Hobbs (UK), John Kjekshu...

Metabolic syndrome (MetS), characterized by central obesity, dyslipidemias, hypertension, and hyperglycemia, impacts 34 percent of the U.S. adult population. MetS has been demonstrated to be affected by dietary components. Data from epidemiological studies and clinical interventions suggest that one or more dairy components might directly affect MetS parameters. For example, calcium has been po...

Liver cancer is the fifth most frequent neoplasm in men and the ninth in women, with 782,000 new cases of cancer diagnosed in 2012, is the second cause of death associated with cancer in the world, with 746,000 deaths in 2012.1 Hepatocellular carcinoma (HCC) is the most common type of liver cancer. It is produced by the transformation of hepatocytes and is common in patients with cirrhosis, con...

The direct link between lipid metabolism alterations and the increase of cardiovascular risk are well documented. Dyslipidemias, including isolated high LDL-c or mixed dyslipidemia, such as those seen in diabetes (hypertriglyceridemia, high LDL-c or low HDL-c), correlate with a significant risk of cardiovascular and cerebrovascular disease worldwide. This review analyzes the current knowledge ...

The progression of atherosclerosis remains a major cause of morbidity and mortality. Plaque formation is an immunological response driven by a number of risk factors, and reduction of risk is the primary goal of treatment. The role of LDL-C is well established and statins have proved effective drugs, although the relative risk reduction is only around 30%. The importance of other factors-notabl...

PPARgamma and PPARdelta agonists represent unique classes of drugs that act through their ability to modulate gene transcription associated with intermediary metabolism, differentiation, tumor suppression, and in some instances proliferation and cell adhesion. PPARgamma agonists are used by millions of people each year to treat type 2 diabetes but may also find additional utility as relatively ...